D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain
IP Chessell, AW Procter, PT Francis, DM Bowen - Brain Research, 1991 - Elsevier
The action of d-Cycloserine (DCS) at the strychnine-insensitive glycine recognition site of
the NMDA receptor-ionophore complex has been studied with membranes from inferior …
the NMDA receptor-ionophore complex has been studied with membranes from inferior …
Characterisation of the Glycine Modulatory Site of the N‐Methyl‐d‐Aspartate Receptor‐Ionophore Complex in Human Brain
AW Procter, GC Stratmann, PT Francis… - Journal of …, 1991 - Wiley Online Library
[3H] Glycine binding and glycine modulation of [3H] MK‐801 binding have been used to
study the glycine allosteric site associated with the N‐methyl‐D‐aspartate receptor complex …
study the glycine allosteric site associated with the N‐methyl‐D‐aspartate receptor complex …
Effects of NMDA modulation in scopolamine dementia.
RW Jones, KA Wesnes, J Kirby - Annals of the New York Academy …, 1991 - europepmc.org
D-Cycloserine is a partial agonist at the strychnine-insensitive neuronal glycine receptor and
positively modulates the N-methyl-D-aspartate (NMDA) excitatory amino acid receptor …
positively modulates the N-methyl-D-aspartate (NMDA) excitatory amino acid receptor …
Actions of D-cycloserine at the N-methyl-D-aspartate-associated glycine receptor site in vivo
MR Emmett, SJ Mick, JA Cler, TS Rao, S Iyengar… - …, 1991 - Elsevier
The antibiotic, d-cycloserine has been shown to be a partial agonist at the N-methyl-d-
aspartate (NMDA)-coupled, strychnine-insensitive glycine receptor by in vitro receptor …
aspartate (NMDA)-coupled, strychnine-insensitive glycine receptor by in vitro receptor …
D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics
WF Hood, RP Compton, JB Monahan - Neuroscience letters, 1989 - Elsevier
We have previously shown that d-cycloserine displaces [3 H] glycine binding to a
recognition site with properties consistent with an N-methyl-d-aspartate (NMDA) receptor …
recognition site with properties consistent with an N-methyl-d-aspartate (NMDA) receptor …
Preservation of Redox, Polyamine, and Glycine Domains of the N‐Methyl‐D‐Aspartate in Alzheimer's Disease
AM Palmer, MA Burns - Journal of neurochemistry, 1994 - Wiley Online Library
This study used [3H] dizocilpine ([3H] MK‐801) binding to the N‐methyl‐D‐aspartate
(NMDA) receptor to examine redox, polyamine, and glycine modulatory sites in membranes …
(NMDA) receptor to examine redox, polyamine, and glycine modulatory sites in membranes …
The N-methyl-D-aspartate receptor complex in Alzheimer's disease: reduced regulation by glycine but not zinc
JE Steele, AM Palmer, GC Stratmann, DM Bowen - Brain research, 1989 - Elsevier
The binding of [3 H] MK-801 to the N-methyl-d-aspartate receptor complex of well-washed
cortical membranes from brains of examples of Alzheimer's disease and controls has been …
cortical membranes from brains of examples of Alzheimer's disease and controls has been …
D-Cycloserine: Agonist turned antagonist
TH Lanthorn - Amino Acids, 1994 - Springer
D-Cycloserine can enhance activation of the NMDA receptor complex and could enhance
the induction of long-term potentiation (LTP). In animals and humans, D-cycloserine can …
the induction of long-term potentiation (LTP). In animals and humans, D-cycloserine can …
D-Cycloserine, a partial agonist at the glycine site, enhances the excitability of dentate granule cells in vivo in rats
M Pitkänen, J Sirviö, H Lahtinen, E Koivisto… - European journal of …, 1994 - Elsevier
The present study investigated the dose-dependent effects of d-cycloserine, a partial agonist
at the glycine modulatory site associated with the NMDA receptor complex, on the …
at the glycine modulatory site associated with the NMDA receptor complex, on the …
Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition.
LH Fossom, AS Basile, P Skolnick - Molecular pharmacology, 1995 - ASPET
Partial agonists at the strychnine-insensitive glycine sites coupled to N-methyl-D-aspartate
(NMDA) receptors reduce both glutamate-induced neurotoxicity in vitro and ischemia …
(NMDA) receptors reduce both glutamate-induced neurotoxicity in vitro and ischemia …