TRPV1: on the road to pain relief
A Jara-Oseguera, SA Simon… - Current molecular …, 2008 - ingentaconnect.com
Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …
propagation of action potentials in the periphery from reaching the brain rather than …
[HTML][HTML] TRP channels: targets for the relief of pain
JD Levine, N Alessandri-Haber - … et Biophysica Acta (BBA)-Molecular Basis …, 2007 - Elsevier
Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …
TRPV1: a therapeutic target for novel analgesic drugs?
A Szallasi, F Cruz, P Geppetti - Trends in molecular medicine, 2006 - cell.com
The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …
Transient receptor potential channels in pain and inflammation: therapeutic opportunities
MA Schumacher - Pain Practice, 2010 - Wiley Online Library
In ancient times, physicians had a limited number of therapies to provide pain relief. Not
surprisingly, plant extracts applied topically often served as the primary analgesic plan. With …
surprisingly, plant extracts applied topically often served as the primary analgesic plan. With …
TRPV1 receptors and signal transduction
T Rosenbaum, SA Simon - TRP ion channel function in sensory …, 2007 - books.google.com
The perception of pain throughout the body arises when neural signals originating from the
terminals of nociceptors are propagated to second-order neurons in the spinal cord or …
terminals of nociceptors are propagated to second-order neurons in the spinal cord or …
Transient receptor potential channels in neuropathic pain
L Basso, C Altier - Current opinion in pharmacology, 2017 - Elsevier
Highlights•Neuropathic pain is a chronic condition that represents a major health
problem.•There is a need for new medications with greater efficacy and less adverse …
problem.•There is a need for new medications with greater efficacy and less adverse …
Role of TRP channels in pain sensation
It is crucial for a living organism to recognize and discern potentially harmful noxious stimuli
from innocuous stimuli to avoid hazards in the environment. However, unnecessary or …
from innocuous stimuli to avoid hazards in the environment. However, unnecessary or …
TRPV1: a target for next generation analgesics
LS Premkumar, P Sikand - Current neuropharmacology, 2008 - ingentaconnect.com
Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …
TRPs and pain
Y Dai - Seminars in Immunopathology, 2016 - Springer
Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …
The functions of TRPA1 and TRPV1: moving away from sensory nerves
ES Fernandes, MA Fernandes… - British journal of …, 2012 - Wiley Online Library
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …
channels are members of the TRP superfamily of structurally related, non‐selective cation …