Peroxisomes are organelles that confine an important set of enzymes within their single
membrane boundaries. In man, a wide variety of genetic disorders is caused by loss of …

Peroxisomes perform a wide variety of metabolic processes in eukaryotic organisms.
Mutations that affect peroxisome function or formation have profound phenotypic …

Peroxisomes, as well as the signals and the machinery that target proteins to this organelle,
are conserved in most eukaryotic organisms. Different peroxisomal targeting signals (PTSs) …

Peroxisomes are eukaryotic organelles that are the subcellular location of important
metabolic reactions. In humans, defects in the organelle's function are often lethal. Yet …

Peroxisomes compartmentalize part of the anabolic and catabolic pathways and reactions of
the cell. Dysfunction of a single peroxisomal enzyme or loss of the whole peroxisomal …

Proteins are targeted to the membrane and matrix of peroxisomes by distinct pathways.
Recent observations suggest a further route: a subset of peroxisomal membrane proteins …

The biogenesis of peroxisomal matrix and membrane proteins is substantially different from
the biogenesis of proteins of other subcellular compartments, such as mitochondria and …

The importance of peroxisomes is highlighted by severe inherited human disorders linked to
impaired peroxisomal biogenesis. Besides the simple architecture of these ubiquitous and …

Peroxisome is a single-membrane organelle in eukaryotes. The functional importance of
peroxisomes in humans is highlighted by peroxisome-deficient peroxisome biogenesis …

A major current issue in studies of peroxisome biogenesis is how proteins are imported into
the organelle or inserted into its membrane. Recent studies indicate that these two …