The integrity of the endothelial barrier between circulating blood and tissue is important for
blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel …

Vascular endothelial (VE)–cadherin forms homotypic adherens junctions (AJs) in the
endothelium, whereas N-cadherin forms heterotypic adhesion between endothelial cells …

Endothelial barrier dysfunction underlies chronic inflammatory diseases. In searching for
new proteins essential to the human endothelial inflammatory response, we have found that …

Endothelial cells (ECs) self-organize into capillary networks when plated on extracellular
matrix. In this process, Rho GTPases-mediated cytoskeletal dynamics control cell movement …

Endothelial cell–cell junctions maintain a restrictive barrier that is tightly regulated to allow
dynamic responses to permeability-inducing angiogenic factors, as well as to inflammatory …

From studies using macrovascular endothelium, it was concluded that Rho A activation
generally leads to endothelial barrier breakdown. Here, we characterized the role of Rho …

Abstract Aims Endothelial cells (ECs) control vascular permeability by forming a monolayer
that is sealed by extracellular junctions. Various mediators modulate the endothelial barrier …

The integrity of the endothelium is dependent on cell-cell adhesion, which is mediated by
vascular-endothelial (VE)-cadherin. Proper VE-cadherin-mediated homotypic adhesion is, in …

Investigating biophysical cellular interactions in the circulation currently requires choosing
between in vivo models, which are difficult to interpret due in part to the hemodynamic and …

The role of the RhoGTPase Rac1 in stabilizing mature endothelial adherens junctions (AJs)
is not well understood. In this paper, using a photoactivatable probe to control Rac1 activity …