We have demonstrated previously that the Rho family GTPase Rac-1 is required for
maintenance of endothelial barrier functions in mouse microvascular myocardial endothelial …

Background Blood vessels comprise endothelial cells, mural cells (pericytes/vascular
smooth muscle cells) and basement membrane. During angiogenesis, mural cells are …

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …

The formation and recovery of gaps in the vascular endothelium governs a wide range of
physiological and pathological phenomena, from angiogenesis to tumor cell extravasation …

Our major theme is that the layered structure of the endothelial barrier requires continuous
activation of signalling pathways regulated by sphingosine‐1‐phosphate (S1P) and …

Epithelial cell-cell interactions require localized adhesive interactions between E-cadherin
on opposing membranes and the activation of downstream signaling pathways that affect …

Spatiotemporal coordination of cell–cell adhesion involving lamellipodial interactions,
cadherin engagement, and the lateral expansion of the contact is poorly understood. Using …

Endothelial cells (ECs) integrate signals from the local microenvironment to guide their
behaviour. RhoA is involved in vascular endothelial growth factor (VEGF)-driven …

RhoGTPases are known regulators of intracellular actin dynamics that are important for
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …

Endothelial cell barrier (EC) properties regulate blood tissue fluid flux. To determine the role
of endothelial-matrix interactions in barrier regulation, we induced cell shrinkage by …