RhoA, RhoB and RhoC differentially regulate endothelial barrier function
MCA Pronk, JSM van Bezu… - Small …, 2019 - Taylor & Francis
RhoGTPases are known regulators of intracellular actin dynamics that are important for
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …
Rap-afadin axis in control of Rho signaling and endothelial barrier recovery
AA Birukova, X Tian, Y Tian… - Molecular biology of …, 2013 - Am Soc Cell Biol
Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability
after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for …
after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for …
A 3D biomimetic model of lymphatics reveals cell–cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex
Impaired lymphatic drainage and lymphedema are major morbidities whose mechanisms
have remained obscure. To study lymphatic drainage and its impairment, we engineered a …
have remained obscure. To study lymphatic drainage and its impairment, we engineered a …
Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier
S Lakshmikanthan, M Sobczak, S Li Calzi… - Journal of cell …, 2018 - journals.biologists.com
Vascular endothelial growth factor (VEGF), a key angiogenic and permeability factor, plays
an important role in new blood vessel formation. However, abnormal VEGF-induced …
an important role in new blood vessel formation. However, abnormal VEGF-induced …
Rap1 signaling in endothelial barrier control
WJ Pannekoek, A Post, JL Bos - Cell adhesion & migration, 2014 - Taylor & Francis
The small G-protein Rap1 plays an important role in the regulation of endothelial barrier
function, a process controlled largely by cell–cell adhesions and their connection to the actin …
function, a process controlled largely by cell–cell adhesions and their connection to the actin …
Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation
Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner
Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC)
barrier accompanies numerous diseases. The EC barrier is established through endothelial …
barrier accompanies numerous diseases. The EC barrier is established through endothelial …
A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis
Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …
Ultra-thin, aligned, free-standing nanofiber membranes to recapitulate multi-layered blood vessel/tissue interface for leukocyte infiltration study
Leukocyte infiltration plays critical roles in tissue inflammation for pathogen clearance and
tumor eradication. This process is regulated by complex microenvironments in blood …
tumor eradication. This process is regulated by complex microenvironments in blood …
RhoA and Rac mediate endothelial cell polarization and detachment induced by T‐cadherin
M Philippova, D Ivanov, R Allenspach… - The FASEB …, 2005 - Wiley Online Library
ABSTRACT T‐cadherin (T‐cad) is an atypical GPI‐anchored member of the cadherin
superfamily. Ligation of T‐cad receptors on endothelial cells prevents cell spreading …
superfamily. Ligation of T‐cad receptors on endothelial cells prevents cell spreading …