RhoGTPases are known regulators of intracellular actin dynamics that are important for
maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator …

Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability
after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for …

Impaired lymphatic drainage and lymphedema are major morbidities whose mechanisms
have remained obscure. To study lymphatic drainage and its impairment, we engineered a …

Vascular endothelial growth factor (VEGF), a key angiogenic and permeability factor, plays
an important role in new blood vessel formation. However, abnormal VEGF-induced …

The small G-protein Rap1 plays an important role in the regulation of endothelial barrier
function, a process controlled largely by cell–cell adhesions and their connection to the actin …

Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …

Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC)
barrier accompanies numerous diseases. The EC barrier is established through endothelial …

Mechanistic understanding of atherosclerosis is largely hampered by the lack of a suitable in
vitro human arterial model that recapitulates the arterial wall structure, and the interplay …

Leukocyte infiltration plays critical roles in tissue inflammation for pathogen clearance and
tumor eradication. This process is regulated by complex microenvironments in blood …

ABSTRACT T‐cadherin (T‐cad) is an atypical GPI‐anchored member of the cadherin
superfamily. Ligation of T‐cad receptors on endothelial cells prevents cell spreading …