Vascular endothelial cadherin (VE-cadherin), which belongs to the classical cadherin family,
is localized at adherens junctions exclusively in vascular endothelial cells. Biochemical and …

Vascular permeability is a complex process involving the coordinated regulation of multiple
signaling pathways in the endothelial cell. It has long been documented that vascular …

Human cell-based 3D tissue constructs play an increasing role in disease modeling and
drug screening. Inflammation, atherosclerosis, and many autoimmune disorders involve the …

Objective—Endothelial cells provide a barrier between the blood and tissues, which is
reduced during inflammation to allow selective passage of molecules and cells. Adherens …

Epithelial intercellular junctions regulate cell-cell contact and mucosal barrier function. Both
tight junctions (TJs) and adherens junctions (AJs) are regulated in part by their affiliation with …

Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

Current in vitro models to test the barrier function of vasculature are based on flat, two-
dimensional monolayers. These monolayers do not have the tubular morphology of …

To establish the role of vascular endothelial (VE)-cadherin in the regulation of endothelial
cell functions, we investigated the effect of phosphorylation of a VE-cadherin site sought to …

Rap1 is a Ras-like GTPase that has been studied with respect to its role in cadherin-based
cell adhesion. Rap1 exists as two separate isoforms, Rap1A and Rap1B, which are 95 …

Endothelial permeability induced by thrombin and histamine is accompanied by actin stress
fibre assembly and intercellular gap formation. Here, we investigate the roles of the Rho …