Vascular endothelial cadherin-mediated cell-cell adhesion regulated by a small GTPase, Rap1
S Fukuhra, A Sakurai, A Yamagishi, K Sako… - BMB …, 2006 - koreascience.kr
Vascular endothelial cadherin (VE-cadherin), which belongs to the classical cadherin family,
is localized at adherens junctions exclusively in vascular endothelial cells. Biochemical and …
is localized at adherens junctions exclusively in vascular endothelial cells. Biochemical and …
[HTML][HTML] The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species
E Monaghan-Benson, K Burridge - Journal of Biological Chemistry, 2009 - ASBMB
Vascular permeability is a complex process involving the coordinated regulation of multiple
signaling pathways in the endothelial cell. It has long been documented that vascular …
signaling pathways in the endothelial cell. It has long been documented that vascular …
Real-time observation of leukocyte–endothelium interactions in tissue-engineered blood vessel
Human cell-based 3D tissue constructs play an increasing role in disease modeling and
drug screening. Inflammation, atherosclerosis, and many autoimmune disorders involve the …
drug screening. Inflammation, atherosclerosis, and many autoimmune disorders involve the …
Crosstalk between reticular adherens junctions and platelet endothelial cell adhesion molecule-1 regulates endothelial barrier function
L Fernández-Martín, B Marcos-Ramiro… - … and Vascular Biology, 2012 - Am Heart Assoc
Objective—Endothelial cells provide a barrier between the blood and tissues, which is
reduced during inflammation to allow selective passage of molecules and cells. Adherens …
reduced during inflammation to allow selective passage of molecules and cells. Adherens …
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin
M Bruewer, AM Hopkins, ME Hobert… - … of Physiology-Cell …, 2004 - journals.physiology.org
Epithelial intercellular junctions regulate cell-cell contact and mucosal barrier function. Both
tight junctions (TJs) and adherens junctions (AJs) are regulated in part by their affiliation with …
tight junctions (TJs) and adherens junctions (AJs) are regulated in part by their affiliation with …
[HTML][HTML] Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling
N Méndez-Barbero, C Gutiérrez-Muñoz… - International journal of …, 2021 - mdpi.com
Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …
[HTML][HTML] 96 perfusable blood vessels to study vascular permeability in vitro
V Van Duinen, A Van Den Heuvel, SJ Trietsch… - Scientific reports, 2017 - nature.com
Current in vitro models to test the barrier function of vasculature are based on flat, two-
dimensional monolayers. These monolayers do not have the tubular morphology of …
dimensional monolayers. These monolayers do not have the tubular morphology of …
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation
K Hatanaka, M Simons… - American Journal of …, 2011 - journals.physiology.org
To establish the role of vascular endothelial (VE)-cadherin in the regulation of endothelial
cell functions, we investigated the effect of phosphorylation of a VE-cadherin site sought to …
cell functions, we investigated the effect of phosphorylation of a VE-cadherin site sought to …
Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions
ES Wittchen, A Aghajanian, K Burridge - Small GTPases, 2011 - Taylor & Francis
Rap1 is a Ras-like GTPase that has been studied with respect to its role in cadherin-based
cell adhesion. Rap1 exists as two separate isoforms, Rap1A and Rap1B, which are 95 …
cell adhesion. Rap1 exists as two separate isoforms, Rap1A and Rap1B, which are 95 …
Rho and Rac but not Cdc42 regulate endothelial cell permeability
B Wójciak-Stothard, S Potempa… - Journal of cell …, 2001 - journals.biologists.com
Endothelial permeability induced by thrombin and histamine is accompanied by actin stress
fibre assembly and intercellular gap formation. Here, we investigate the roles of the Rho …
fibre assembly and intercellular gap formation. Here, we investigate the roles of the Rho …