Rac1, a member of the Rho family small GTPases, regulates E-cadherin-mediated cell-cell
adhesion. However, it remains to be clarified how the localization and activation of Rac1 are …

Rap1 is a small GTPase regulating cell–cell adhesion, cell–matrix adhesion, and actin
rearrangements, all processes dynamically coordinated during cell spreading and …

Endothelial permeability induced by thrombin and histamine is accompanied by actin stress
fibre assembly and intercellular gap formation. Here, we investigate the roles of the Rho …

Alterations in the mechanical properties of erythrocytes occurring in inflammatory and
haematological disorders such as sickle-cell disease (SCD) and malaria often lead to …

Rap1 and Rap2 are closely related proteins of the Ras family of small G-proteins. Rap1 is
well known to regulate cell-cell adhesion. Here, we have analysed the effect of Rap …

Vascular endothelial (VE)-cadherin is a cell–cell adhesion molecule involved in endothelial
barrier functions. Previously, we reported that cAMP-Epac-Rap1 signal enhances VE …

Changes in vascular endothelial (VE)-cadherin–mediated cell-cell adhesion and integrin-
mediated cell-matrix adhesion coordinate to affect the physical and mechanical …

In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …

Lifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately,
cardiovascular adverse events. Rodent models are commonly used to investigate …

Background The marrow microenvironment and vasculature plays a critical role in regulating
hematopoietic cell recruitment, residence, and maturation. Extensive in vitro and in vivo …