Molecular basis of endothelial cell morphogenesis in three‐dimensional extracellular matrices

GE Davis, KJ Bayless, A Mavila - The Anatomical Record: An …, 2002 - Wiley Online Library
Although many studies have focused on blood vessel development and new blood vessel
formation associated with disease processes, the question of how endothelial cells (ECs) …

Endothelial cells and organ function: applications and implications of understanding unique and reciprocal remodelling

M Reiterer, CM Branco - The FEBS Journal, 2020 - Wiley Online Library
The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform

EA Margolis, DS Cleveland, YP Kong, JA Beamish… - Lab on a Chip, 2021 - pubs.rsc.org
Supportive stromal cells of mesenchymal origins regulate vascular morphogenesis in
developmental, pathological, and regenerative contexts, contributing to vessel formation …

Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow

E Bosseboeuf, A Chikh, AB Chaker, TP Mitchell… - Science …, 2023 - science.org
Linear and disturbed flow differentially regulate gene expression, with disturbed flow priming
endothelial cells (ECs) for a proinflammatory, atheroprone expression profile and …

Microcirculation-on-a-chip: a microfluidic platform for assaying blood-and lymphatic-vessel permeability

M Sato, N Sasaki, M Ato, S Hirakawa, K Sato, K Sato - PloS one, 2015 - journals.plos.org
We developed a microfluidic model of microcirculation containing both blood and lymphatic
vessels for examining vascular permeability. The designed microfluidic device harbors …

An essential role for Rac1 in endothelial cell function and vascular development

W Tan, TR Palmby, J Gavard… - The FASEB …, 2008 - Wiley Online Library
Numerous cell surface receptors, including tyrosine kinase and G protein‐coupled
receptors, play critical roles in endothelial cell function and blood vessel development …

Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks

MB Curtis, N Kelly, CCW Hughes, SC George - Scientific reports, 2022 - nature.com
Endothelial cells line all major blood vessels and serve as integral regulators of many
functions including vessel diameter, cellular trafficking, and transport of soluble mediators …

Endothelial contractile cytoskeleton and microvascular permeability

Q Shen, MH Wu, SY Yuan - Cell health and cytoskeleton, 2009 - Taylor & Francis
Microvascular barrier dysfunction represents a significant problem in clinical conditions
associated with trauma, burn, sepsis, acute respiratory distress syndrome, ischemia …

RAC1 regulates adherens junctions through endocytosis of E-cadherin

N Akhtar, NA Hotchin - Molecular biology of the cell, 2001 - Am Soc Cell Biol
The establishment of cadherin-dependent cell–cell contacts in human epidermal
keratinocytes are known to be regulated by the Rac1 small GTP-binding protein, although …

Regulation of fibronectin matrix assembly and capillary morphogenesis in endothelial cells by Rho family GTPases

S Fernandez-Sauze, D Grall, B Cseh… - Experimental cell …, 2009 - Elsevier
Fibronectin (FN) fibrillogenesis is an essential biological process mediated by α5β1 integrin
and cellular contractile forces. Assembly of a FN matrix by activated endothelial cells occurs …