Genome editing tools have revolutionized the generation of genetically modified animals
including livestock. In particular, the domestic pig is a proven model of human physiology …

Spermatogonial stem cell transplantation (SSCT) is an experimental technique for transfer of
germline between donor and recipient males that could be used as a tool for biomedical …

Gene editing technologies, such as CRISPR-Cas9, have important applications in
mammalian embryos for generating novel animal models in biomedical research and lines …

Co-injection of zygotes with Cas9 mRNA and sgRNA has been proven to be an efficient
gene-editing strategy for genome modification of different species. Genetic engineering in …

The CRISPR/Cas9 system has been adapted as an efficient genome editing tool in
laboratory animals such as mice, rats, zebrafish and pigs. Here, we report that …

The domestic pig is an ideal “dual purpose” animal model for agricultural and biomedical
research. With the availability of genome editing tools such as clustered regularly …

Transgenic technologies used for creating a desired genomic change in animals involve
three critical steps: isolation of fertilized eggs, microinjection of transgenic DNA into them …

Developing a safe and effective male contraceptive remains a challenge in the field of
medical science. Molecules that selectively target the male reproductive tract and whose …

The beginning of this century has witnessed great advances in the understanding of ovarian
physiology and embryo development, in the improvement of assisted reproductive …

Dear Editor, Type1diabetes (T1D) is a lifelong (chronic) disease and a major health problem
throughout the world. This disease can be treated by either insulin injection or islet …