Tumors harbor diverse compartments of cells with distinct metabolic properties and
phenotypes, but the mechanism by which metabolic commensalism among distinct subsets …

Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells
exhibit increased secretion of lactate, which creates an acidic tumor microenvironment …

Colorectal cancer (CRC) is one of the most common cancers worldwide, which ranks third in
terms of incidence and the second leading cause of cancer-related mortality. Metabolic …

Cancer stem cells play critical roles in tumor initiation, progression, and relapse. Since we
previously found that GATA6 promotes the stemness in HCT‐116 and HT‐29 human …

Reprogramming energy metabolism, such as enhanced glycolysis, is an Achilles' heel in
cancer treatment. Most studies have been performed on isolated cancer cells. Here, we …

Abstract Purpose of Review Metabolic reprogramming is essential for the rapid proliferation
of cancer cells and is thus recognized as a hallmark of cancer. In this review, we will discuss …

Simple Summary Accumulating evidence indicates the existence of cancer stem cells
(CSCs) sub-populations which fuel cancer growth and maintain stemness in different …

Cancer stem‐like cells (CSCs) are thought to be the main cause of tumor occurrence,
progression and therapeutic resistance. Strong research efforts in the last decade have led …

Colorectal cancer (CRC) is a heterogeneous group of diseases that are the result of
abnormal glucose metabolism alterations with high lactate production by pyruvate to lactate …

Colorectal cancer (CRC) is a major cause of morbidity and mortality in the United States.
Tumor-stromal metabolic crosstalk in the tumor microenvironment promotes CRC …