[HTML][HTML] Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model
R Wang, J Li, X Xu, J Xu, H Jiang, Z Lv, R Wu… - Journal of Orthopaedic …, 2021 - Elsevier
Background Synovial inflammation plays a major role in the pathogenesis of osteoarthritis
(OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation …
(OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation …
Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis
W Yan, H Yu, B Liu, Z Jiang, H Jin, Z Li, L Li, D Zou… - Transplant …, 2022 - Elsevier
Background Andrographolide (AD) has been reported to play a potential anti-arthritic role by
facilitating the proliferation and inhibiting the apoptosis of chondrocytes. However, the …
facilitating the proliferation and inhibiting the apoptosis of chondrocytes. However, the …
Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes
Q Ding, X Ji, Y Cheng, Y Yu, Y Qi… - Modern rheumatology, 2013 - academic.oup.com
Objective The aim of this study was to investigate the effects of andrographolide on matrix
metalloproteinases (MMP) 1, 3, and 13 and inducible nitric oxide synthase (iNOS) in human …
metalloproteinases (MMP) 1, 3, and 13 and inducible nitric oxide synthase (iNOS) in human …
Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways
Z Li, J Tan, L Wang, Q Li - Inflammation, 2017 - Springer
Andrographolide (AD) is the main compound distributed in medicinal herb Andrographis
paniculata and exhibits anti-inflammatory activity. AD has been used for the treatment of …
paniculata and exhibits anti-inflammatory activity. AD has been used for the treatment of …
Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines
Ethnopharmacological relevance Traditional plant-derived medicines have enabled the
mankind in curing the wide spectrum of diseases throughout the ages. Andrographis …
mankind in curing the wide spectrum of diseases throughout the ages. Andrographis …
Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study
L Luo, Q Wei, L Liu, L Zheng… - … and Alternative Medicine, 2015 - Wiley Online Library
As the main active constituent of Andrographis paniculata that was applied in treatment of
many diseases including inflammation in ancient China, andrographolide (ANDRO) was …
many diseases including inflammation in ancient China, andrographolide (ANDRO) was …
Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway
B Li, T Jiang, H Liu, Z Miao, D Fang… - Journal of cellular …, 2019 - Wiley Online Library
Recent studies have shown that andrographolide (AP) has the potential to be developed as
a drug for therapy for osteoarthritis (OA). However, the role of AP in attenuating the …
a drug for therapy for osteoarthritis (OA). However, the role of AP in attenuating the …
Andrographolide mitigates cartilage damage via miR‐27‐3p‐modulated matrix metalloproteinase13 repression
S Chen, Z Luo, X Chen - The Journal of Gene Medicine, 2020 - Wiley Online Library
Background As a potential anti‐arthritic agent, Andrographolide (And) is capable of
promoting chondrocyte proliferation and preventing apoptosis in pathologic condition. The …
promoting chondrocyte proliferation and preventing apoptosis in pathologic condition. The …
Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis–NETosis balance of neutrophils
X Li, K Yuan, Q Zhu, Q Lu, H Jiang, M Zhu… - International journal of …, 2019 - mdpi.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetric
polyarthritis with swelling and pain at synovial joints. In RA patients, delayed neutrophil …
polyarthritis with swelling and pain at synovial joints. In RA patients, delayed neutrophil …
Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis
Andrographolide, a diterpenoid lactone obtained from plant Andrographis paniculata, is
used in South Asian countries to relieve various inflammatory symptoms. To study the effects …
used in South Asian countries to relieve various inflammatory symptoms. To study the effects …