[HTML][HTML] Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
TG Normile, TH Chu, BS Sheridan, M Del Poeta - Mucosal immunology, 2022 - Elsevier
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …
[HTML][HTML] Cryptococcus neoformans Δsgl1 Vaccination Requires Either CD4+ or CD8+ T Cells for Complete Host Protection
TG Normile, A Rella, M Del Poeta - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Cryptococcus neoformans is a fungal pathogen causing life-threatening
meningoencephalitis in susceptible individuals. Fungal vaccine development has been …
meningoencephalitis in susceptible individuals. Fungal vaccine development has been …
[HTML][HTML] Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development
A Rella, V Mor, AM Farnoud, A Singh… - Frontiers in …, 2015 - frontiersin.org
Cryptococcosis caused by Cryptococcus neoformans and Cryptococcus gattii affects a large
population and is a cause of significant morbidity and mortality. Despite its public health …
population and is a cause of significant morbidity and mortality. Despite its public health …
[HTML][HTML] Three models of vaccination strategies against cryptococcosis in immunocompromised hosts using heat-killed Cryptococcus neoformans Δsgl1
TG Normile, M Del Poeta - Frontiers in Immunology, 2022 - frontiersin.org
Vaccines are one of the greatest medical accomplishments to date, yet no fungal vaccines
are currently available in humans mainly because opportunistic mycoses generally occur …
are currently available in humans mainly because opportunistic mycoses generally occur …
Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model
AC Colombo, A Rella, T Normile, LS Joffe, PM Tavares… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …
[PDF][PDF] Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and …
CA Specht, CK Lee, H Huang, MM Hester, J Liu… - 2017 - core.ac.uk
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and …
CA Specht, CK Lee, H Huang, MM Hester, J Liu… - MBio, 2017 - Am Soc Microbiol
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …
Improved Survival of Mice Deficient in Secretory Immunoglobulin M following Systemic Infection with Cryptococcus neoformans
KS Subramaniam, K Datta, MS Marks… - Infection and …, 2010 - Am Soc Microbiol
Cryptococcus neoformans causes severe, and often fatal, disease (cryptococcosis) in
immunocompromised patients, particularly in those with HIV/AIDS. Although resistance to …
immunocompromised patients, particularly in those with HIV/AIDS. Although resistance to …
[HTML][HTML] Glucosylceramide administration as a vaccination strategy in mouse models of cryptococcosis
V Mor, AM Farnoud, A Singh, A Rella, H Tanno, K Ishii… - PloS one, 2016 - journals.plos.org
Cryptococcus neoformans is an opportunistic fungal pathogen and the causative agent of
the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and in …
the disease cryptococcosis. Cryptococcosis is initiated as a pulmonary infection and in …
Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts
Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …