Cryptococcus gattii capsule blocks surface recognition required for dendritic cell maturation independent of internalization and antigen processing

SM Huston, P Ngamskulrungroj, RF Xiang… - The Journal of …, 2016 - journals.aai.org
Cryptococcus gattii is an emerging fungal pathogen on the west coast of Canada and the
United States that causes a potentially fatal infection in otherwise healthy individuals. In …

Direct Inhibition of T-Cell Responses by the Cryptococcus Capsular Polysaccharide Glucuronoxylomannan

LE Yauch, JS Lam, SM Levitz - PLoS pathogens, 2006 - journals.plos.org
The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is
the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high …

Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection

IF LaRocque-de-Freitas, JDB Rocha, MP Nunes… - ScIentIFIc …, 2018 - nature.com
Cryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in
immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or …

Evaluation of Cryptococcus neoformans galactoxylomannan–protein conjugate as vaccine candidate against murine cryptococcosis

SK Chow, A Casadevall - Vaccine, 2011 - Elsevier
Galactoxylomannan (GalXM) is a complex polysaccharide produced by the human
pathogenic fungus Cryptococcus neoformans that mediates profound immunological …

Accumulation of γδ T cells in the lungs and their regulatory roles in Th1 response and host defense against pulmonary infection with Cryptococcus neoformans

K Uezu, K Kawakami, K Miyagi, Y Kinjo… - The Journal of …, 2004 - journals.aai.org
The present study was designed to elucidate the role of γδ T cells in the host defense
against pulmonary infection with Cryptococcus neoformans. The γδ T cells in lungs …

[PDF][PDF] Regulation by innate immune T lymphocytes in the host defense against pulmonary infection with Cryptococcus neoformans

K Kawakami - Japanese journal of infectious diseases, 2004 - niid.go.jp
Recently, innate immune lymphocytes, such as natural killer (NK) T cells and γδ antigen
receptor-bearing T (γδ T) cells, have garnered much attention, and their biological …

Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes

MCC Van Dyke, AK Chaturvedi, SE Hardison… - Frontiers in …, 2017 - frontiersin.org
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …

The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection

EB da Silva-Junior, L Firmino-Cruz… - Scientific Reports, 2021 - nature.com
Abstract Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi,
such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its …

[HTML][HTML] Anti-glucuronoxylomannan IgG1 specific antibodies production in Cryptococcus neoformans resistant mice

C Parra, JM González, E Castañeda, S Fiorentino - Biomedica, 2005 - scielo.org.co
Abstract PARRA, Claudia; GONZALEZ, John Mario; CASTANEDA, Elizabeth and
FIORENTINO, Susana. Anti-glucuronoxylomannan IgG1 specific antibodies production in …

A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection

R Fleuridor, A Lees, L Pirofski - The Journal of Immunology, 2001 - journals.aai.org
Abstract Defined Abs to the Cryptococcus neoformans capsular polysaccharide
glucuronoxylomannan (GXM) have been shown to be protective against experimental …