Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF …
Background Heart failure with mildly reduced or preserved ejection fraction (hereafter
referred to as HFpEF) is the most common type of heart failure and is associated with a high …
referred to as HFpEF) is the most common type of heart failure and is associated with a high …
[HTML][HTML] Semaglutide in patients with heart failure with preserved ejection fraction and obesity
MN Kosiborod, SZ Abildstrøm, BA Borlaug… - … England Journal of …, 2023 - Mass Medical Soc
Background Heart failure with preserved ejection fraction is increasing in prevalence and is
associated with a high symptom burden and functional impairment, especially in persons …
associated with a high symptom burden and functional impairment, especially in persons …
Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
J Deanfield, S Verma, BM Scirica, SE Kahn… - The Lancet, 2024 - thelancet.com
Background Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse
cardiovascular events (MACE) in people with overweight or obesity, but the effects of this …
cardiovascular events (MACE) in people with overweight or obesity, but the effects of this …
Semaglutide in patients with obesity-related heart failure and type 2 diabetes
MN Kosiborod, MC Petrie, BA Borlaug… - … England Journal of …, 2024 - Mass Medical Soc
Background Obesity and type 2 diabetes are prevalent in patients with heart failure with
preserved ejection fraction and are characterized by a high symptom burden. No approved …
preserved ejection fraction and are characterized by a high symptom burden. No approved …
Semaglutide in patients with obesity and heart failure across mildly reduced or preserved ejection fraction
J Butler, SZ Abildstrøm, BA Borlaug, MJ Davies… - Journal of the American …, 2023 - jacc.org
Background Many therapies for heart failure (HF) have shown differential impact across the
spectrum of left ventricular ejection fraction (LVEF). Objectives In this prespecified analysis …
spectrum of left ventricular ejection fraction (LVEF). Objectives In this prespecified analysis …
Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial
BA Borlaug, DW Kitzman, MJ Davies, S Rasmussen… - Nature medicine, 2023 - nature.com
In the STEP-HFpEF trial, semaglutide improved symptoms, physical limitations and exercise
function and reduced body weight in patients with obesity phenotype of heart failure and …
function and reduced body weight in patients with obesity phenotype of heart failure and …
Effects of semaglutide on symptoms, function, and quality of life in patients with heart failure with preserved ejection fraction and obesity: a prespecified analysis of the …
MN Kosiborod, S Verma, BA Borlaug, J Butler… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Patients with heart failure (HF) with preserved ejection fraction (HFpEF)
and obesity experience a high burden of symptoms and functional impairment, and a poor …
and obesity experience a high burden of symptoms and functional impairment, and a poor …
Semaglutide and NYHA functional class in obesity-related heart failure with preserved ejection fraction: the STEP-HFpEF program
M Schou, MC Petrie, BA Borlaug, J Butler… - Journal of the American …, 2024 - jacc.org
Abstract Background In the Semaglutide Treatment Effect in People with obesity and HFpEF
(STEP-HFpEF) program, semaglutide improved heart failure (HF)-related symptoms …
(STEP-HFpEF) program, semaglutide improved heart failure (HF)-related symptoms …
Design and baseline characteristics of STEP-HFpEF program evaluating semaglutide in patients with obesity HFpEF phenotype
MN Kosiborod, SZ Abildstrøm, BA Borlaug, J Butler… - Heart Failure, 2023 - jacc.org
Background The majority of patients with heart failure with preserved ejection fraction
(HFpEF) have the obesity phenotype, but no therapies specifically targeting obesity in …
(HFpEF) have the obesity phenotype, but no therapies specifically targeting obesity in …
Effects of semaglutide on heart failure outcomes in diabetes and chronic kidney disease in the FLOW trial
RE Pratley, KR Tuttle, P Rossing, S Rasmussen… - Journal of the American …, 2024 - jacc.org
Background People with type 2 diabetes (T2D) and chronic kidney disease (CKD) are at
high risk for heart failure (HF) and premature death from cardiovascular (CV) causes. The …
high risk for heart failure (HF) and premature death from cardiovascular (CV) causes. The …