Aim: Disclosing the mechanisms that regulate reprogramming memory. Materials &
methods: We established computational procedure to find DNA methylation somatic memory …

Global DNA demethylation is an integral part of reprogramming processes in vivo and in
vitro, but whether it occurs in the derivation of induced pluripotent stem cells (iPSCs) is not …

Genomic imprinting is an epigenetic mechanism that causes functional differences between
paternal and maternal genomes, and plays an essential role in mammalian development …

Epigenetic properties of cultured embryonic stem cells (ESC s), including DNA methylation
imprinting, are important because they affect the developmental potential. Here, we tested a …

DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …

A central question of biology is the basis of stable cell fates. Cell fates are formed during
development, where the zygote progresses from totipotency to terminal differentiation. Each …

Gene expression regulation is gated by promoter methylation states modulating transcription
factor binding. The known DNA methylation/unmethylation mechanisms are sequence …

Background Imprinted loci are paradigms of epigenetic regulation and are associated with a
number of genetic disorders in human. A key characteristic of imprints is the presence of a …

The technology of induced pluripotent stem cell (iPS) provides the possibility to reverse the
terminal differentiated cells to pluripotent stem cells, and is therefore of great importance in …

ZFP57 is required to maintain the germline-marked differential methylation at imprinting
control regions (ICRs) in mouse embryonic stem cells (ESCs). Although DNA methylation …