Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by …

HK Jyrkkänen, S Kuosmanen, M Heinäniemi… - Biochemical …, 2011 - portlandpress.com
BACH1 is a repressor of transcription via competitive binding to the MARE (Maf-… BACH1
is a transcriptional repressor that is regulated at multiple levels. Haem binds to BACH1 and …

Redox regulation of the transcriptional repressor Bach1

M Ishikawa, S Numazawa, T Yoshida - Free Radical Biology and Medicine, 2005 - Elsevier
Bach1 is a transcriptional repressor of heme oxygenase-1, one of the most inducible phase
2 proteins. Bach1 … protein to tandem repeats of the antioxidant response element (ARE) and …

BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite

JF Reichard, MA Sartor, A Puga - Journal of Biological Chemistry, 2008 - ASBMB
… and that BACH1 inactivation is … BACH1 is thought to interact with antioxidant response
element motifs, we further examined the role of BACH1 as a regulator of inducible antioxidant

Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate …

JW Kaspar, AK Jaiswal - Journal of Biological Chemistry, 2010 - ASBMB
Bach1, a transcriptional repressor of the heme oxygenase gene, localizes in the nucleus
under normal conditions. The heavy metal cadmium and heme induced chromosomal region …

… regulation of the antioxidant response element (ARE)-mediated NAD (P) H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants

S Dhakshinamoorthy, AK Jain, DA Bloom… - Journal of Biological …, 2005 - ASBMB
… The heavy metal cadmium induced the nuclear export of Bach1, a transcriptional repressor
… in response to antioxidants. We demonstrate that overexpression of Bach1 represses …

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

JF Reichard, GT Motz, A Puga - Nucleic acids research, 2007 - academic.oup.com
… To characterize activation of the antioxidant response following arsenite exposure, we first
characterized cellular and subcellular changes in NRF2 and BACH1 disposition. In control …

Bach2 is a potent repressor of Nrf2-mediated antioxidant enzyme expression in dopaminergic neurons

EA Waxman - BioRxiv, 2019 - biorxiv.org
… transcriptional repressors Bach1 and Bach2 that inhibit Nrf2 responses and prevent antioxidant
… in dopaminergic neurons in mediating Nrf2 antioxidant responses. We hypothesized that …

Oxidative Stress Regulates CFTR Gene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element

Z Zhang, SH Leir, A Harris - American journal of respiratory cell and …, 2015 - atsjournals.org
… initiation of the antioxidant response (Figure E2). Significant Bach1 enrichment was only …
Bach1 acts as a constitutive repressor at the ARE within DHS-44kb under normal conditions…

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells

H Zhang, L Zhou, KJA Davies, HJ Forman - Archives of biochemistry and …, 2019 - Elsevier
Bach1, a repressor of Nrf2 signaling. In this limited follow-up study, we explored how Bach1
… in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

BACH1 mediates the antioxidant properties of aged garlic extract

T Tsuneyoshi - Experimental and Therapeutic …, 2020 - spandidos-publications.com
… the Nrf2‑dependent antioxidant response. Neither S1PC nor SAC … 1 (BACH1), a transcriptional
repressor that competes with … Nrf2 binds to antioxidant response elements (AREs) that are …