Safety evaluation of ocular drug delivery formulations: techniques and practical considerations

BG Short - Toxicologic pathology, 2008 - journals.sagepub.com
formulations and permeability enhancers. Intravitreal, subconjunctival, and periocular routes
of administration and sustained-release formulations of … implants to deliver drugs to the …

Drug safety assessment of oral formulations of ketoconazole

AK Gupta, D Daigle, KA Foley - Expert opinion on drug safety, 2015 - Taylor & Francis
… Areas covered: This drug safety review summarizes reports of oral ketoconazole-related
adverse events retrieved from a search of the PubMed database using the search strategy ‘…

Advances in nutraceutical delivery systems: From formulation design for bioavailability enhancement to efficacy and safety evaluation

RFS Gonçalves, JT Martins, CMM Duarte… - Trends in Food Science …, 2018 - Elsevier
drug delivery system (SEDDS) composed of Capmul MCM as the oil phase, Tween 20 as
surfactant and ethanol as co-surfactant and its stability and antioxidant capacity was evaluated. …

[图书][B] Drug safety evaluation

SC Gad - 2016 - books.google.com
… Most of what will be presented and discussed in this volume speaks to regulatory
requirements for nonclinical safety assessment in the general case for either small molecules or …

Drug delivery and formulations

J Breitkreutz, J Boos - Pediatric Clinical Pharmacology, 2011 - Springer
Drug delivery to children is still a major challenge. Key issues are age-appropriate formulations,
safety of excipients, suitability of drug delivery devices and therapy compliance. Some …

Nanomedicines for ocular NSAIDs: safety on drug delivery

J Araújo, E Gonzalez, MA Egea, ML Garcia… - … , Biology and Medicine, 2009 - Elsevier
drugs are used in eye surgery. In this review we focus on microemulsions, polymeric
nanoparticles, liposomes, solid lipid nanoparticles, and drug nanocrystals as formulations

Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges

H Wen, H Jung, X Li - The AAPS journal, 2015 - Springer
… ten drugs using sterile long-acting release (LAR) formulations … , drug delivery systems have
been used in delaying drug … type of formulation design more risky from safety perspective. …

Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern

PL Lam, WY Wong, Z Bian, CH Chui, R Gambari - Nanomedicine, 2017 - Taylor & Francis
… This review highlights the potential risks of nanomedicine formulations to health, delivery
routes of … Nanoscale formulation has been used for drug delivery over the last decade. This …

Cyclodextrin complexes: Perspective from drug delivery and formulation

S Jacob, AB Nair - Drug development research, 2018 - Wiley Online Library
evaluation of haematology and pathophysiology (Stella & He, 2008). A number of safety
evaluations … maltosyl β-CD are practically nontoxic and safe when administered parenteral. The …

Improvement of drug safety by the use of lipid-based nanocarriers

SB Lim, A Banerjee, H Önyüksel - Journal of controlled release, 2012 - Elsevier
… in drug formulation is one approach to improve drug safety. Lipid-… review we will illustrate
how lipid based nanocarriers can overcome drug resistance and provide targeted drug delivery