[HTML][HTML] Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-β
YQ Xiao, K Malcolm, GS Worthen, S Gardai… - Journal of Biological …, 2002 - ASBMB
… Here we show that blockade of p38 MAPK by the p38 inhibitor SB 203580 also inhibited
the LPS-stimulated generation of TNF-α and MIP-2, whereas once again the CC chemokine …
the LPS-stimulated generation of TNF-α and MIP-2, whereas once again the CC chemokine …
[HTML][HTML] Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
… ), a highly selective p38α MAPK inhibitor [26], for its effects on p38α MAPK activity and tau
… We report here that MW181 suppresses p38α MAPK activation, reduces tau phosphorylation…
… We report here that MW181 suppresses p38α MAPK activation, reduces tau phosphorylation…
RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and-γ selectivity, suppresses COPD inflammation
… p38 MAPK activation is increased in the lungs of COPD patients, and p38 MAPK inhibitors
suppress … However, p38 MAPK inhibitors have shown variable effects in COPD clinical trials, …
suppress … However, p38 MAPK inhibitors have shown variable effects in COPD clinical trials, …
Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase
JA Nick, SK Young, PG Arndt, JG Lieber… - The Journal of …, 2002 - journals.aai.org
… was accomplished with the compound M39, which is a highly selective and bioavailable
inhibitor of p38 MAPK (28). Herein we report the effect of poststimulation inhibition of …
inhibitor of p38 MAPK (28). Herein we report the effect of poststimulation inhibition of …
Novel strategies for inhibition of the p38 MAPK pathway
J Zhang, B Shen, A Lin - Trends in pharmacological sciences, 2007 - cell.com
… Here, we discuss alternative strategies that might lead to better p38 inhibitors, including
non-ATP-competitive inhibitors and inhibitors that are targeted to other components of the …
non-ATP-competitive inhibitors and inhibitors that are targeted to other components of the …
Inhibition of p38 MAP kinase as a therapeutic strategy
JC Lee, S Kumar, DE Griswold, DC Underwood… - …, 2000 - Elsevier
… selective inhibitors of p38 MAP kinase. SB 203580 inhibits the catalytic activity of p38 MAP
kinase … may be involved in mediating IL-10-induced effects (eg, suppression of tumor necrosis …
kinase … may be involved in mediating IL-10-induced effects (eg, suppression of tumor necrosis …
The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer
HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
… regulated/activated kinase (PRAK), which are selectively phosphorylated by p38 MAPK. …
plays multiple roles in physiological systems other than inflammation, suppression of this kinase …
plays multiple roles in physiological systems other than inflammation, suppression of this kinase …
Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma
P Bhavsar, N Khorasani, M Hew… - European …, 2010 - Eur Respiratory Soc
… Selective inhibitors of p38 MAPK, mainly the α isoform, have been developed. In seeking …
p38 MAPK activation in corticosteroid sensitivity, we examined whether inhibitors of p38 MAPK …
p38 MAPK activation in corticosteroid sensitivity, we examined whether inhibitors of p38 MAPK …
The pathways to tumor suppression via route p38
J Han, P Sun - Trends in biochemical sciences, 2007 - cell.com
… These isoforms differ in tissue distributions, regulation by upstream stimuli, and selectivity …
Raf–MEK–ERK MAPK pathway and the stress-induced MINK–MKK3/6–p38–PRAK …
Raf–MEK–ERK MAPK pathway and the stress-induced MINK–MKK3/6–p38–PRAK …
[HTML][HTML] Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-α (TNF-α) mRNA induction: evidence for selective destabilization of TNF-α …
K Rutault, CA Hazzalin, LC Mahadevan - Journal of Biological Chemistry, 2001 - ASBMB
… We have studied the role of ERK and p38 mitogen-activated … of ERK and p38 MAP kinase
inhibitors. Furthermore, … that inhibition of p38 MAP kinase selectively destabilizes TNF-…
inhibitors. Furthermore, … that inhibition of p38 MAP kinase selectively destabilizes TNF-…
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