… somatic cells into embryonic stem cells (ESCs)-like cells using the four exogenous factors:
Oct3/4, SOX2, c-Myc, and KLF4 [1]. The resulting cells termed induced Pluripotent Stem Cells (…

… stem cell research. In this review, we highlight the basic biology and application of the
CRISPR/Cas9 system in current human stem cell … for human stem cells in regenerative medicine. …

… CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide
screens in human cells … sensitivity of human stem cell lines to transformed cells lines. Two …

… CRISPR/Cas9 system in cell lines did not translate into high editing activity in primary cell
types such as human primary T cells … 'all RNA'-based CRISPR/Cas9 system highly effective in …

… stem cells followed by autologous transplantation could be used to cure β-haemoglobinopathies.
Here we present a CRISPR/Cas9 gene-editing system that combines Cas9 … stem cells. …

… Spermatogonial stem cells (SSCs) can produce numerous male gametes after … introduced
into SSCs using the CRISPR-Cas9 system. We used the CRISPR-Cas9 system to mutate an …

… However, the establishment of human pluripotent stem cell (… hPSC lines by combining
CRISPR/Cas9-mediated genome … embryonic stem cell (hESC) and induced pluripotent stem cell (…

… of CRISPR/Cas9 use in the context of human reproduction, to modify embryos, germline cells,
and pluripotent stem cells is … Finally, the possible uses and consequences of CRISPR/cas9 …

… personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem
cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in …

… However, the CRISPR/Cas9-edited autologous HSCs have … In this review, we summarized
the possibility of CRISPR/Cas9-… improvements of CRISPR/cas9-mediated autologous HSCT. …