Gene targeting in stem cells from individuals with osteogenesis imperfecta
JR Chamberlain, U Schwarze, PR Wang, RK Hirata… - Science, 2004 - science.org
… from individuals with the brittle bone disorder osteogenesis imperfecta, demonstrating
successful gene targeting in adult human stem cells. Osteogenesis imperfecta (OI) is caused by …
successful gene targeting in adult human stem cells. Osteogenesis imperfecta (OI) is caused by …
Stem cell therapy as a treatment for osteogenesis imperfecta
C Götherström, L Walther-Jallow - Current osteoporosis reports, 2020 - Springer
… Pre- and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis
imperfecta: a two-center experience. Stem Cells Transl Med. 2014;3(2):255–64. https://doi.org/…
imperfecta: a two-center experience. Stem Cells Transl Med. 2014;3(2):255–64. https://doi.org/…
Mesenchymal stem cells in the treatment of osteogenesis imperfecta
E Lang, JA Semon - Cell Regeneration, 2023 - Springer
… Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting …
use of cell therapy to correct the underlying molecular defects of OI. Mesenchymal stem cells (…
use of cell therapy to correct the underlying molecular defects of OI. Mesenchymal stem cells (…
Mesenchymal stem cell therapy for osteogenesis imperfecta
C Götherström, AL David… - Clinical Obstetrics …, 2021 - journals.lww.com
… osteogenesis imperfecta (OI) with mesenchymal stem cells (MSCs). MSCs ability to migrate,
engraft, and differentiate into bone cells … tissues makes these cells promising candidates as …
engraft, and differentiate into bone cells … tissues makes these cells promising candidates as …
Pre-and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience
C Götherström, M Westgren, SWS Shaw… - Stem cells …, 2014 - academic.oup.com
… in selection of the appropriate stem cell type and preparation will be … stem cell transplantation
for OI is still a highly experimental therapy. From experience in other fields of stem cell …
for OI is still a highly experimental therapy. From experience in other fields of stem cell …
Osteogenesis imperfecta
A Forlino, JC Marini - The Lancet, 2016 - thelancet.com
… Also, in the Brtl mouse model for classic osteogenesis imperfecta, which is heterozygous
for an α1(I) Gly349Cys substitution, mesenchymal stem cells, precursors to both osteoblasts …
for an α1(I) Gly349Cys substitution, mesenchymal stem cells, precursors to both osteoblasts …
Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta
JR Chamberlain, DR Deyle, U Schwarze, P Wang… - Molecular Therapy, 2008 - cell.com
… Figure 1COL1A2 gene targeting in osteogenesis imperfecta mesenchymal stem cells (OI
MSCs). (a) Schematic representation of the gene-targeting vector AAV-COL2e4INloxpA shown …
MSCs). (a) Schematic representation of the gene-targeting vector AAV-COL2e4INloxpA shown …
Normal collagen and bone production by gene-targeted human osteogenesis imperfecta iPSCs
DR Deyle, IF Khan, G Ren, PR Wang, J Kho… - Molecular Therapy, 2012 - cell.com
… Figure 1Stem cell engineering strategy for osteogenesis imperfecta (OI). Schematic
representation of proposed therapeutic approach for OI based on autologous, gene-targeted, …
representation of proposed therapeutic approach for OI based on autologous, gene-targeted, …
Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta
K Le Blanc, C Götherström, O Ringdén, M Hassan… - …, 2005 - journals.lww.com
… fetal MSC as the donor cell source for the intrauterine transplantation, hypothesizing that
they propagate better than adult MSC in the fetal environment. Osteogenesis imperfecta (OI) is …
they propagate better than adult MSC in the fetal environment. Osteogenesis imperfecta (OI) is …
Osteogenesis imperfecta, rehabilitation medicine, fundamental research and mesenchymal stem cells
AI Caplan - Connective tissue research, 1995 - Taylor & Francis
… cell for mesenchymatous tissues can be isolated from marrow or periosteum. This cell, referred
to as a Mesenchymal Stem Cell … tissues have reasonably high cellular turnover rates. If …
to as a Mesenchymal Stem Cell … tissues have reasonably high cellular turnover rates. If …
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