Erlotinib after gefitinib failure in relapsed non-small cell lung cancer: clinical benefit with optimal patient selection

A Hata, N Katakami, H Yoshioka, S Fujita, K Kunimasa… - Lung cancer, 2011 - Elsevier
study was a significant predictive factor for erlotinib therapy. … of gefitinib and erlotinib could
be performed in our study. Thus, … of sensitivity to erlotinib therapy after gefitinib failure. Further …

Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4)

H Murakami, T Tamura, T Takahashi… - Cancer chemotherapy …, 2012 - Springer
… were enrolled in this study, and 12 patients were treated (five men and … treated with afatinib
20 mg/day, three patients were treated with afatinib 40 mg/day and six patients were treated

Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancer

Y Togashi, K Masago, S Masuda, T Mizuno… - Cancer chemotherapy …, 2012 - Springer
… Thus, in the present study, we investigated the plasma and … -TKI treatment (250 mg daily
gefitinib or 150 mg daily erlotinib) … 15 patients received gefitinib and erlotinib treatment; therefore…

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a …

C Zhou, YL Wu, G Chen, J Feng, XQ Liu… - The lancet …, 2011 - thelancet.com
… as first-line therapy for advanced NSCLC, gefitinib was associated with a … gefitinib. We do
not believe that there is a need to a head-to-head clinical trial between gefinitib and erlotinib; …

Successful treatment of two lung cancer patients with erlotinib following gefitinib-induced hepatotoxicity

GY Ku, A Chopra, G de Lima Lopes Jr - Lung Cancer, 2010 - Elsevier
therapy with gefitinib 250 mg daily after thorough discussion … to gefitinib treatment can
be safely switched to erlotinib. In … CR by the first patient on erlotinib suggests that anti-tumor …

[HTML][HTML] A retrospective comparison of the clinical efficacy of gefitinib, erlotinib, and afatinib in Japanese patients with non-small cell lung cancer

A Fujiwara, M Yoshida, H Fujimoto, H Nakahara… - … research, 2018 - ncbi.nlm.nih.gov
… -line therapy is still a controversial issue. The aim of this study was to compare the effectiveness
of gefitinib, erlotinib, and … NSCLC including 147 patients treated with EGFR TKIs. Time to …

Use of the epidermal growth factor receptor inhibitors gefitinib, erlotinib, afatinib, dacomitinib, and icotinib in the treatment of non-small-cell lung cancer: a systematic …

PM Ellis, N Coakley, R Feld, S Kuruvilla, YC Ung - Current oncology, 2015 - mdpi.com
… No relevant systematic reviews that answered our research questions were identified. …
The os with gefitinib therapy trended longer in the mutation-positive subgroup (hr: 0.78; 95% ci: …

[HTML][HTML] Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib

E Vasile, C Tibaldi, A Chella, A Falcone - Journal of Thoracic Oncology, 2008 - Elsevier
treated with erlotinib after progression of disease to gefitinib. … suggested that erlotinib could
be more efficacious than gefitinib, … out a study to evaluate the activity of erlotinib in advanced …

[HTML][HTML] A phase III, randomized, open-label study of ASP8273 versus erlotinib or gefitinib in patients with advanced stage IIIB/IV non-small-cell lung cancer

RJ Kelly, FA Shepherd, A Krivoshik, F Jie, L Horn - Annals of Oncology, 2019 - Elsevier
… , but patients with exon 20 point mutations from another phase I study (NCT02113813)
without available standard-of-care therapies could continue ASP8273 under revised consent …

Gefitinib or Erlotinib vs Chemotherapy for EGFR Mutation-Positive Lung Cancer: Individual Patient Data Meta-Analysis of Overall Survival

CK Lee, L Davies, YL Wu, T Mitsudomi… - JNCI: Journal of the …, 2017 - academic.oup.com
study, the primary objective was to determine the pooled overall treatment effect on OS of
firstline therapy with gefitinib … this meta-analysis of gefitinib and erlotinib as most of the included …