… after Tyrosine Kinase Inhibitor Discontinuation in Patients with EGFR-Mutant Lung Cancer and Acquired Resistance to Erlotinib or Gefitinib: Implications for Clinical …

JE Chaft, GR Oxnard, CS Sima, MG Kris, VA Miller… - … cancer research, 2011 - AACR
… enrolled on clinical trials of agents to treat acquired resistance to erlotinib or gefitinib. …
mandated TKI discontinuation before administration of study therapy. Disease flare was defined as …

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… Median PFS in 217 patients treated with erlotinib was 14 … the European Tarceva versus
Chemotherapy (EURTAC) study, … either erlotinib or gefitinib, dependent on the standard of care at …

[HTML][HTML] Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy

YL Li, X Hu, QY Li, F Wang… - Molecular …, 2018 - spandidos-publications.com
… of the present study suggested that shikonin could promote erlotinib/gefitinib-induced apoptosis
… The dose of erlotinib/gefitinib selected in the present study was not expected to exhibit …

[HTML][HTML] Comparison of effectiveness and adverse effects of gefitinib, erlotinib and icotinib among patients with non‑small cell lung cancer: A network meta‑analysis

Y Liu, Y Zhang, G Feng, Q Niu… - Experimental and …, 2017 - spandidos-publications.com
… the success rate of gefitinib, erlotinib and icotinib have been reported. In the current study, a
… effects of gefitinib, erlotinib and icotinib for the treatment of patients with advanced NSCLC. …

Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839,'Iressa') on an expanded access study

PA Jänne, S Gurubhagavatula, BY Yeap, J Lucca… - Lung cancer, 2004 - Elsevier
therapy were instructed to interrupt gefitinib treatment during treatment. Patients who required
… of separate clinical studies of single agent gefitinib and erlotinib in patients with BAC. …

Erlotinib as a salvage treatment for patients with advanced non-small cell lung cancer after failure of gefitinib treatment

Z Song, Y Yu, Z Chen, S Lu - Chinese Medical Journal, 2011 - mednexus.org
… t if frd 1i ne treat me nt of NSCLC e spec i al ly among never -… QoL) and pr ol onged t he s
urvi val ti me in pr evious studies … the study and all of th em we rea ss es s abl e f or r es pons e …

[HTML][HTML] Prospective assessment of continuation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of …

N Yoshimura, K Okishio, S Mitsuoka, T Kimura… - Journal of Thoracic …, 2013 - Elsevier
… Twenty-seven patients were enrolled in this study. The median number of … In conclusion,
we showed that combined pemetrexed and erlotinib or gefitinib therapy after the relapse to …

Combined γ-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells

SV Bachawal, VB Wali, PW Sylvester - Anticancer research, 2010 - ar.iiarjournals.org
… However, results in the present study showed that combined γ-tocotrienol and erlotinib or
gefitinib treatment had no effect on the Src activation, and suggests that combined treatment-…

[HTML][HTML] Symptom and quality of life benefit of afatinib in advanced non–small-cell lung cancer patients previously treated with erlotinib or gefitinib: results of a …

V Hirsh, J Cadranel, XJ Cong, D Fairclough… - Journal of Thoracic …, 2013 - Elsevier
… beyond the first follow-up visit postprogression may have alleviated the issue of missing data;
however, this could have led to the occurrence of several potential challenges in this study: …

Successful treatment of non-small cell lung cancer with gefitinib after severe erlotinib-related hepatotoxicity

K Kunimasa, H Yoshioka, M Iwasaku, A Nishiyama… - Internal …, 2012 - jstage.jst.go.jp
… However, several studies have documented the effectiveness … gefitinib treatment due to its
higher penetration rate to cerebrospinal fluid. For these reasons, we chose erlotinib treatment