The p38 MAP kinase pathway as a therapeutic target in inflammatory disease
J Saklatvala - Current opinion in pharmacology, 2004 - Elsevier
… Inhibiting the MAPK pathway as an anti-inflammatory therapy might not … p38 MAPK itself;
targets upstream or downstream could also be blocked. As discussed below, the pathway is …
targets upstream or downstream could also be blocked. As discussed below, the pathway is …
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
… p38 MAPK inhibition and in vivo evaluation of p38 MAPK significance to various aspects of
AD pathology is still missing, the p38 MAPK … on the role of p38 MAPK in neurodegeneration, …
AD pathology is still missing, the p38 MAPK … on the role of p38 MAPK in neurodegeneration, …
p38 pathway kinases as anti-inflammatory drug targets
JF Schindler, JB Monahan… - Journal of dental …, 2007 - journals.sagepub.com
… Scientific exploration of this pathway from biological, cellular, and in vivo perspectives was …
inhibitors of p38 MAPK that target the α and β isoforms. p38 MAPK pathway function is critical …
inhibitors of p38 MAPK that target the α and β isoforms. p38 MAPK pathway function is critical …
The p38 MAP kinase pathway and its biological function
L New, J Han - Trends in cardiovascular medicine, 1998 - Elsevier
… Thus, the p38 MAP kinase cascade may consist of the … other potential regulators of the
p38 pathway have been defined. … search of proteins targeted for phosphorylation by p38 and, …
p38 pathway have been defined. … search of proteins targeted for phosphorylation by p38 and, …
Novel strategies for inhibition of the p38 MAPK pathway
J Zhang, B Shen, A Lin - Trends in pharmacological sciences, 2007 - cell.com
… inhibitors and inhibitors that are targeted to other components of the signaling pathway. …
ATP to the protein targeted for phosphorylation. Many p38 target proteins are important kinases …
ATP to the protein targeted for phosphorylation. Many p38 target proteins are important kinases …
p38 signalling pathway
JJ Sanz-Ezquerro, A Cuenda - International Journal of Molecular …, 2021 - mdpi.com
… and obesity; they also discuss p38MAPK role in pathological conditions leading to type II
diabetes and the possibility of targeting these kinases in therapies for diabetes treatment [10]. …
diabetes and the possibility of targeting these kinases in therapies for diabetes treatment [10]. …
MAP kinase pathways activated by stress: the p38 MAPK pathway
T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
… Direct substrates of p38 MAPK, as well as their downstream targets, are listed in Table 2.
Transcriptional control regions containing elements for both CREB and ATF1 are strongly …
Transcriptional control regions containing elements for both CREB and ATF1 are strongly …
[HTML][HTML] p38 MAP-kinases pathway regulation, function and role in human diseases
A Cuenda, S Rousseau - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
… by a MAPK kinase kinase (MKKK). The MKKK responsible for activating the p38 MAPK
pathways … Thus inhibition of p38 MAPK may provide beneficial therapeutic target in some human …
pathways … Thus inhibition of p38 MAPK may provide beneficial therapeutic target in some human …
Mechanisms and functions of p38 MAPK signalling
A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
… MAPK families that usually function as parallel pathways in … provide an overview of the p38
MAPK pathway, which is strongly … based on targeted deletion of several p38 MAPK pathway …
MAPK pathway, which is strongly … based on targeted deletion of several p38 MAPK pathway …
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling
… -derived precursor cells blocked for p38 MAPK activity and the mi/… target of the p38 MAPK
in osteoclasts. In this study, we investigate whether MITF is a potential target of the p38 MAPK …
in osteoclasts. In this study, we investigate whether MITF is a potential target of the p38 MAPK …
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