[HTML][HTML] Human γδ TCR repertoires in health and disease

AS Fichtner, S Ravens, I Prinz - Cells, 2020 - mdpi.com
… -throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire
… cell subsets can mount an adaptive-like immune response [33,34]. Yet, data monitoring the …

[HTML][HTML] Genetic and environmental determinants of human TCR repertoire diversity

C Krishna, D Chowell, M Gönen, Y Elhanati, TA Chan - Immunity & Ageing, 2020 - Springer
… cell response [29]. Altogether, these data suggest that CMV diminishes TCR repertoire
diversity… demonstrating dramatic reduction of the antibody repertoire after measles infection [30]—…

[HTML][HTML] Sequence analysis of T-cell repertoires in health and disease

DJ Woodsworth, M Castellarin, RA Holt - Genome medicine, 2013 - Springer
… review, the T-cell receptor (TCR) repertoire has been found … Beyond pathogen and vaccine
responses, TCR-seq will also … broader human microbiome, as exemplified by a recent TCR-…

Human adaptive immune receptor repertoire analysis—past, present, and future

SCA Nielsen, SD Boyd - Immunological reviews, 2018 - Wiley Online Library
… Here, we will review recent progress in understanding Ig and TCR repertoires with the tools
… applied by many investigators to analyze human responses to influenza virus infection and …

Analysis of TCR usage in human tumors: a new tool for assessing tumor-specific immune responses

M Sensi, G Parmiani - Immunology today, 1995 - cell.com
… Studies of the TCR repertoire expressed by TILs in neoplastic lesions were initiated on the
… immune response dominated by oligoclonal T cells, thus exhibiting a limited set of TCR otl3 …

Diversity and clonal selection in the human T-cell repertoire

Q Qi, Y Liu, Y Cheng, J Glanville… - Proceedings of the …, 2014 - National Acad Sciences
T-cell receptor repertoire owing to thymic involution has been implicated as causing defective
immune responses … statistical analysis, we find that human TCR repertoires are an order of …

[HTML][HTML] Characteristics of TCR repertoire associated with successful immune checkpoint therapy responses

J Kidman, N Principe, M Watson, T Lassmann… - Frontiers in …, 2020 - frontiersin.org
… Most TCR diversity arises from the β chain because it utilizes an additional … human peripheral
blood samples (21, 22). In this review, we refer to TCR repertoire as the collection of TCRs

[HTML][HTML] High-resolution analysis of the human T-cell receptor repertoire

E Ruggiero, JP Nicolay, R Fronza, A Arens… - Nature …, 2015 - nature.com
… constitution in different immunological conditions, we have performed TCR repertoire
analysis on at least two biological human replicates. Samples from 6 healthy donors, 2 CMV-…

[HTML][HTML] Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

MS Davey, CR Willcox, SP Joyce, K Ladell… - Nature …, 2017 - nature.com
… to human Vδ2 neg T cells, implicated in responses to viral infection and cancer. The prevalent
Vδ1 T cell receptor (TCR) repertoire … proliferative capacity and TCR sensitivity, displaying …

In VivoLongitudinal Analysis of a Dominant TCR Repertoire Selected in Human Response to Influenza Virus

A Prevost-Blondel, R Lengagne, F Letourneur… - Virology, 1997 - Elsevier
… -specific CTL response. In contrast, in the course of a study on the cellular response to influenza
A … Sanguine (Paris, France) and the kinetics of an antigen-selected TCR repertoire in im- …