The effect of benzo [alpha] pyrene on DNA methylation and telomerase activity in human normal and cancer cells

R Zarei, D Moghadam, MM Sarabi, F Naghibalhossaini - Toxicology in Vitro, 2022 - Elsevier
methylation levels in 3 cancer cell lines (HCT16, PC3, and A549), as measured by ELISA
assay. BaP also reduced telomerase enzyme activitytelomerase activity and DNA methylation

The influence of polymorphisms of xenobiotic-metabolizing and DNA repair genes in DNA damage, telomere length and global DNA methylation evaluated in open …

MR de Souza, P Rohr, VFS Kahl, K Kvitko… - Ecotoxicology and …, 2020 - Elsevier
… Significant decrease in % of global DNA methylation were observed in CYP1A1 Val/- exposed
individuals compared to CYP1A1 Ile/Ile individuals. Coal workers who carried the XRCC4 …

Benzo [a] pyrene decreases global and gene specific DNA methylation during zebrafish development

X Fang, C Thornton, BE Scheffler, KL Willett - Environmental toxicology and …, 2013 - Elsevier
… both global and gene specific DNA methylation of five … ), telomerase reverse transcriptase
(tert), c-jun and c-myca. In addition, gene expression and enzyme activity of two methylation

Influence of benzo (a) pyrene on different epigenetic processes

B Bukowska, P Sicińska - International Journal of Molecular Sciences, 2021 - mdpi.com
… global as well as specific DNA methylation of a specific gene… [a]pyrene (BPDE) to study
modulation of DNA methylation in … member 1 (RASSF1), telomerase reverse transcriptase (TERT)…

Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons

S Pavanello, AC Pesatori, L Dioni, M Hoxha… - …, 2010 - academic.oup.com
… Benzo[ a ]pyrene (BP), which has been used as a tracer of … Global DNA hypermethylation
following in vitro chronic exposure … In particular, PAH(BP)–DNA adducts and DNA methylation

Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells

B Sadikovic, DI Rodenhiser - Toxicology and applied pharmacology, 2006 - Elsevier
… (a)pyrene (BaP), leads to covalent DNA modifications and … cellular growth dynamics and
DNA methylation in four breast … , this is at the telomeric region of this particular chromosome. …

Mitochondrial DNA copy number and exposure to polycyclic aromatic hydrocarbons

S Pavanello, L Dioni, M Hoxha, U Fedeli… - … , biomarkers & prevention, 2013 - AACR
… [a]pyrene) released after acid hydrolysis of DNA samples, as … of telomere length measurements,
we amplified telomere (T) … DNA methylation in p53 gene was quantified as previously …

Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution

B Fougère, Y Landkocz, C Lepers, PJ Martin… - Experimental …, 2018 - Elsevier
… time that the increase of telomere length and telomerase activity after exposure to particles
… modification of DNA methylation patterns, characterized by the hypermethylation of specific …

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

A Alhamdow, C Lindh, J Hagberg, P Graff… - …, 2018 - academic.oup.com
Telomere length, mtDNA copy number and DNA methylation of F2RL3 and AHRR in … pyrene,
fluoranthene and phenanthrene, in addition to BaP (about 9–30% of the amount of pyrene) (…

Epigenetic effects of benzo (a) pyrene in Fundulus heteroclitus and Danio rerio

X Fang - 2011 - egrove.olemiss.edu
… or gene expression in Ras-association domain family member 1 (RASSF1), telomerase
In conclusion, BaP can cause global and gene specific DNA methylation changes in zebrafish …