… It antagonizes TGF-β signalling through multiple mechanisms in the cytoplasm and in the …
by TGF-β and other growth factors and serves as an important cross-talk mediator of the TGF-β …

… Other positive and negative regulators of the Smad pathway can also mediate cross talk
with the canonical Wnt pathway. For example, Smurf1 and Smurf2 have been shown to inhibit …

… understanding of the molecular mechanisms that may mediate these cooperative effects. …
reveals variable requirement for Smad4 in transforming growth factor β-related signaling. J Biol …

… Basic modes of signaling cross-talk. A cross-talk exists between pathways A and B when …
(c) one signal modulates or competes for a key modulator or mediator (“M”) of the other. In this …

… In addition, we have identified TGF-β-induced TAK1 as an upstream mediator of IKKα/β
phosphorylation and activation, leading to phosphorylation and degradation of the NF-κB …

… to the TGF-β signaling pathway, which is highlighted by cross-talk … Thus, a full understanding
of how TGF-β is able to relay the … TGF-β, is believed to mediate the induction of apoptosis by …

… However, the molecular mechanisms that mediate this antagonistic effect are … by TGF-β
signaling. We provide evidence that this two-way cross-talk between the estrogen and TGF-β …

… PKC signal pathway may cross-talk with TGF-β signaling by … about Smad6’s role as a
mediator for cross-talking with other … TGF-β superfamily signaling and as the mediators of cross…

… pathway, TGF- is capable of utilising non-Smad effectors to mediate some of its biological
responses, including nonreceptor protein tyrosine kinases such as Src and FAK, mediators of …

… Some of these appear to be dependent upon TGFβ. In this study, we have investigated
interplay between these two mediators that may be highly relevant to the development of …