SMADs: mediators and regulators of TGF-β signaling
M Kretzschmar, J Massagué - Current opinion in genetics & development, 1998 - Elsevier
… This study reports the identification of Smad3 as a mediator of TGF-~ signaling and demonstrates
that different SMADs (ie Smad3 and Smad4) synergize to achieve high levels of TGF-~ …
that different SMADs (ie Smad3 and Smad4) synergize to achieve high levels of TGF-~ …
Transforming growth factor β signaling mediators and modulators
CM Zimmerman, RW Padgett - Gene, 2000 - Elsevier
… regulators, but also suggested that Smads may be the only required mediators of TGFβ-…
The hypothesis that Smads might be physiological regulators of transcriptional responses was …
The hypothesis that Smads might be physiological regulators of transcriptional responses was …
TGF-β: the master regulator of fibrosis
… The central role of TGF-β1 as a negative regulator of the immune response, in particular, …
of TGF-β1 in CKD. Indeed, concerns about the potential adverse effects of targeting TGF-β1 has …
of TGF-β1 in CKD. Indeed, concerns about the potential adverse effects of targeting TGF-β1 has …
TGF-beta: a master immune regulator
C Larson, B Oronsky, CA Carter, A Oronsky… - Expert opinion on …, 2020 - Taylor & Francis
… to explain the differential clinical response patterns to anti-PD-1 therapy, the TGF-β pathway
was identified as the key mediator of checkpoint inhibitor resistance [Citation37]. Similarly, …
was identified as the key mediator of checkpoint inhibitor resistance [Citation37]. Similarly, …
Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling
X Yan, YG Chen - Biochemical Journal, 2011 - portlandpress.com
… a key negative regulator [4,14,15]. Moreover, Smad7 was also found to connect the TGF-β …
the current understanding of Smad7 as both a regulator and a mediator of TGF-β signalling. …
the current understanding of Smad7 as both a regulator and a mediator of TGF-β signalling. …
Positive and negative regulation of TGF-β signaling
K Miyazono - Journal of cell science, 2000 - journals.biologists.com
… that overexpression or constitutive activation of negative regulators of TGF-β signaling (ie
I-… of TGF-β and transformation of cells. It will be interesting to determine how these regulatory …
I-… of TGF-β and transformation of cells. It will be interesting to determine how these regulatory …
Regulation of immune responses by TGF-β
JJ Letterio, AB Roberts - Annual review of immunology, 1998 - annualreviews.org
… In addition to these roles in diseasepathogenesis, TGF-β is now established as a principal
mediator of oraltolerance and can be recognized as the sine qua non of a unique subset …
mediator of oraltolerance and can be recognized as the sine qua non of a unique subset …
New regulatory mechanisms of TGF-β receptor function
JS Kang, C Liu, R Derynck - Trends in cell biology, 2009 - cell.com
… its role in defining the cell responses to TGF-β. Indeed, the receptor availability and function
… the regulation of receptor function in the context of previous knowledge of TGF-β receptor …
… the regulation of receptor function in the context of previous knowledge of TGF-β receptor …
The regulation of TGFβ signal transduction
A Moustakas, CH Heldin - Development, 2009 - journals.biologists.com
… Transforming growth factor β (TGFβ) pathways are implicated in metazoan development, …
3, TGFβ family transcriptional regulation in development also occurs via the regulation of micro-…
3, TGFβ family transcriptional regulation in development also occurs via the regulation of micro-…
Smad regulation in TGF-β signal transduction
A Moustakas, S Souchelnytskyi… - Journal of cell …, 2001 - journals.biologists.com
… transduce signals from transforming growth factor-β (TGF-β) … of complexes with the common
mediator Smad (Co-Smad), … facilitating target gene regulation by TGF-β. Smads themselves …
mediator Smad (Co-Smad), … facilitating target gene regulation by TGF-β. Smads themselves …
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