… Of note, reduced deposition of ECM in these mice could be abolished by exogenous TGF-β1,
implicating that ECM gene regulation by TGF-β may also occur via SMAD3-independent …

… interactions during embryogenesis, mediation of cell and tissue … Regulation of production
and turnover of ECM components is essential for tissue homeostasis and function. TGF-β …

… Thus, non-Smad signal transducers under the control of TGF-β provide quantitative regulation
of … that Smads are crucial mediators of this process downstream of TGF-β, because they …

… inhibited TGF-β-induced expression of fibronectin and HMGA2, a central mediator of
epithelial–mesenchymal transition (EMT), suggesting a novel mechanism involving mitochondria in …

… , is permissive for regulation of gene expression and growth suppression by TGF-β in LNCaP
… stability of TβRII mRNA and reversal of TGF-β-mediated TβRII mRNA loss. Changes in …

… recognized mediators of immune regulation is the cytokine transforming growth factor-β (TGF-β), …
Emerging data have unveiled a pivotal role for TGF-β as a perpetrator of suppression by …

… Transforming growth factor-β (TGFβ) is the prototype for a … Important intracellular mediators
of TGFβ signaling are … molecules involved in TGFβ signaling and their regulation by post-…

… In summary, these results provide the possibility that the regulation of I-Smad genes, in
particular … TGF-β superfamily signaling and as the mediators of crosstalkings with other signaling …

… TGF-β signals are conveyed through type I and type II … -Thr) kinases, to specific intracellular
mediators known as the Smad … stem cell regulation, including those encoding TGF-β pathway …

… regulator that promote TGF-β1-mediated tissue fibrosis, while Smad7 serves as a negative
feedback regulator of TGF-β1/… TGF-β1 is a key mediator in the development of fibrosis and …