TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
EH Budi, JR Schaub, M Decaris, S Turner… - The Journal of …, 2021 - Wiley Online Library
… TGF-β1 as a key regulator of macrophage recruitment and functions in the fibrotic lesions.
Less is known about the extent to which TGF-β … role as a major mediator of TGF-β-induced, …
Less is known about the extent to which TGF-β … role as a major mediator of TGF-β-induced, …
Transforming growth factor beta (TGF-β) and inflammation in cancer
B Bierie, HL Moses - Cytokine & growth factor reviews, 2010 - Elsevier
… regulation of tumor initiation, progression and metastasis. The regulation of tumorigenesis by
TGF-β … TGF-β was initially identified as a functional mediator of epithelial and fibroblast cell …
TGF-β … TGF-β was initially identified as a functional mediator of epithelial and fibroblast cell …
Specificity and versatility in TGF-β signaling through Smads
XH Feng, R Derynck - Annu. Rev. Cell Dev. Biol., 2005 - annualreviews.org
… , which constitutes a critical point for negative regulation of TGF-β signaling. Most notably, …
, a negative regulator of Wnt signaling with which several Wnt signaling mediators interact. …
, a negative regulator of Wnt signaling with which several Wnt signaling mediators interact. …
Immunoregulation by members of the TGFβ superfamily
WJ Chen, P Ten Dijke - Nature Reviews Immunology, 2016 - nature.com
… different and some shared signalling mediators. Similarly to TGFβ, activins signal through their
… focus on the emerging roles of activins and BMPs in the regulation of immune cell activity. …
… focus on the emerging roles of activins and BMPs in the regulation of immune cell activity. …
Regulation of the bioavailability of TGF-β and TGF-β-related proteins
IB Robertson, DB Rifkin - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
… TGF-β signaling in a larger biological context. Here, we review the extracellular regulation of
TGF-β … TGF-β is also an important mediator of immune tolerance, and conditional deletion of …
TGF-β … TGF-β is also an important mediator of immune tolerance, and conditional deletion of …
Klf10 and Klf11 as mediators of TGF-beta superfamily signaling
B Spittau, K Krieglstein - Cell and tissue research, 2012 - Springer
… the regulation and induction by the various TGF-beta … regulation by TGF-beta superfamily
members. Moreover, we summarize the involvement of Klf10 and Klf11 in the regulation of TGF-…
members. Moreover, we summarize the involvement of Klf10 and Klf11 in the regulation of TGF-…
TGFβ signalling in control of T-cell-mediated self-reactivity
YP Rubtsov, AY Rudensky - Nature Reviews Immunology, 2007 - nature.com
… , the transmission of TGFβ signals is finely tuned by multiple layers of regulation at almost …
transforming growth factor β by human T lymphocytes and its potential role in the regulation …
transforming growth factor β by human T lymphocytes and its potential role in the regulation …
TGF-β signaling in vascular fibrosis
M Ruiz-Ortega, J Rodríguez-Vita… - Cardiovascular …, 2007 - academic.oup.com
… TGF-β has long been believed to be the most important extracellular matrix regulator. We …
of mediators and crosstalk between pathways, as we discuss here in detail. On the other hand, …
of mediators and crosstalk between pathways, as we discuss here in detail. On the other hand, …
[HTML][HTML] The logic of TGFβ signaling
J Massagué, RR Gomis - FEBS letters, 2006 - Elsevier
… transforming growth factor β … family represents a most remarkable paradigm of regulatory
versatility. … TGFβ has been shown to activate other mediators such as the mitogen-activated …
versatility. … TGFβ has been shown to activate other mediators such as the mitogen-activated …
Mechanisms of TGF-β-mediated apoptosis
N Schuster, K Krieglstein - Cell and tissue research, 2002 - Springer
… from cell-culture experiments and in vivo data that TGF-β is a key mediator of B- and T-cell …
of work remains concerning the regulatory molecules and their importance for TGF-β-induced …
of work remains concerning the regulatory molecules and their importance for TGF-β-induced …