… TGF-β is a master regulator of both physiological (wound healing) and pathological … as
major downstream mediators of sGC - cGMP pathway in the regulation of vascular tone and …

… receptors and signaling mediators. This review summarizes the discovery of TGF-β, the early
… supported the role of TGF-β as an endogenous negative regulator of proliferation of several …

… by the TGF-β receptors. Endoglin phosphorylation seems to play a regulatory role for
ALK1-… GSK-3β is apparently one of the major mediators of environment-dependent TGF-β-induced …

… is the essential mediator of TGF-β signaling and directly activates genes encoding regulators
of … for immediate-early target genes of TGF-β but absent in intermediate target genes. In …

… aberrations in this central regulatory pathway give precedence for investigation of TGF-…
immune and inflammatory mediators that provide additional cytokines and growth factors upon …

… Besides Smurfs and phosphatases, Smad7 was shown to promote the recruitment of
mediators of Smad-independent pathways to the TGF- β type I receptor. Which binding partner(s) …

… By gene expression profiling, we identified TGF-β-dependent … contribute to the regulation
of TGF-β responses to varying … mediator of TGF-β-induced cell cycle arrest in HaCaT cells. …

… that TGF-β is the key mediator in CKD associated with progressive renal fibrosis. It is well
documented that TGF-β1 … Moreover, the regulatory mechanism of Smad7 on TGF-β signaling …

… Indeed, the up-regulation of TGF-β appears prevalent in all … expression for both TGF-β1 and
the type II TGF-β receptor are … production of various downstream mediators of TGF-β. These …

… with fibrotic diseases and TGF-β is a primary inducer of collagen, this study was undertaken
to examine the possible role of sphingolipids in TGF-β regulation of collagen production. …