… To conclude, we attempt to relate the structure or 'wiring' of TGFβ–SMAD signal
transduction to its physiological functions, and take a look at future challenges in the field. …

… the transforming growth factor β (TGFβ) signaling pathway … recent findings on TGFβ signaling
during receptor endocytosis… taken by TGFβ receptors, their impact on active TGFβ signaling …

… Thus, in order to further characterize the impact of ER expression on TGF-β signal transduction,
we transiently overexpressed ER-α in MDA435 ER-negative breast cancer cells. The …

… known to play important roles in TGFβ signaling. Ubiquitin modifications thus play a key role
in TGFβ signal transduction, and in this review we … Transforming growth factor β signaling …

… -signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In
this review, we focused on three major signal transduction … three signal transduction pathways…

… The TGF-β family comprises many structurally related … cell surface and an intracellular signal
transducing Smad complex. The … simplicity of the signal transduction mechanism with few …

… for regulating TGF-β signal transduction … for TGF-β signaling, suggesting that continuous
cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. …

… rather than by having simisignal transducers, in transducing the TGFfl signal. As in lar
sequences. … The firstinvertebrate ponents in the TGFfl signal transduction pathway. For member …

… that influence the TGF-β pathway demonstrates that signal transduction does not proceed in
a … The present review describes the intricate control of TGF-β signal transduction on various …

… may be due to elevated levels of TGF-β signaling that strengthens dynamic reciprocity in the
tumor microenvironment. We review how TGF-β signaling influences the ECM structure and …