Transforming growth factor–β (TGF-β) superfamily members regulate a plethora of developmental
processes, and disruption of their activity has been implicated in a variety of human …

… Transforming growth factor‐β (TGF‐β) superfamily members … In contrast to the still growing
TGF‐β superfamily (with ~30 … specificity between different TGF‐β superfamily members is …

… TGF‐β superfamily in mammals, and can be classified based on whether they activate
activin/TGF‐β… Understanding the mechanisms of TGF‐β superfamily signalling is thus important for …

… In this review, we first describe in detail how the TGF-β superfamily signaling pathways
are altered in human cancer. We then go on to assess, where possible, the clinical …

… of the superfamily include … TGF-β superfamily share the same dimeric structure in which
the central 3–1/2 turn helix of one monomer packs against the concave surface formed by the β-…

… The human transforming growth factor-β (TGFβ) superfamily … Different TGFβ superfamily
members may have overlapping … All 33 TGFβ superfamily members signal via structurally …

… The transforming growth factor β (TGF-β) signaling pathway plays a key role in different …
The TGF-β coreceptors endoglin and betaglycan are emerging as modulators of the TGF-β …

… The purpose of this review is to describe the biochemical properties of the TGF-β superfamily
… Known ligand-binding properties and nomenclature for the TGF-β superfamily receptors …

… transforming growth factor-β (TGFβ) superfamily in cancer has revolved around the TGFβ …
deregulated signalling by many of the other superfamily members also has crucial roles in both …

… The phospho-relay from TGF-β superfamily receptor kinases to downstream Smad …
controls TGF-β superfamily signaling at each step in this physiologically important pathway. …