Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

RS Hotchkiss, G Monneret, D Payen - The Lancet infectious diseases, 2013 - thelancet.com
… that occurs in sepsis, and explain why many previous sepsis trials which were … use in sepsis.
We hypothesise that immunoadjuvant therapy represents the next major advance in sepsis. …

Is neuroimmunomodulation a future therapeutic approach for sepsis?

V Kumar, A Sharma - International immunopharmacology, 2010 - Elsevier
sepsis. Therefore pharmacologic stimulation of vagus nerve to release Ach may prove better
therapeutic approach to treat bacterial sepsis. … response responsible for sepsis by binding to …

A new therapeutic approach for the treatment of sepsis

AB Iskit, MO Guc - Medical hypotheses, 2004 - Elsevier
therapeutic modality, the unrelenting hypotension which is the hallmark of patients dying from
septic shock, has dominated all therapeutic … the first step of the sepsis cascade which might …

Sepsis: from historical aspects to novel vistas. Pathogenic and therapeutic considerations

T Magrone, E Jirillo - Endocrine, Metabolic & Immune Disorders …, 2019 - ingentaconnect.com
sepsis is propaedeutic to the illustration of novel therapeutic attempts for the prevention or
attenuation of experimental sepsis … new therapeutic approaches for the treatment of sepsis will …

Therapeutic approaches to innate immunity: severe sepsis and septic shock

E Lolis, R Bucala - Nature reviews Drug discovery, 2003 - nature.com
… Severe sepsis leading to shock is the principal cause of death in … therapeutic development.
This article discusses selected pathophysiological mechanisms that might yield to therapeutic

[HTML][HTML] Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?

D Kojic, BH Siegler, F Uhle, C Lichtenstern… - World journal of …, 2015 - ncbi.nlm.nih.gov
… linking diagnostic results to an individual therapeutic regime - also termed … sepsis. Thus,
beside the need to find valuable diagnostic substances, biomarker-guided therapy approaches

Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

S Esposito, G De Simone, G Boccia, F De Caro… - Journal of global …, 2017 - Elsevier
… Despite advances in management, sepsis and septic shock still … and therapeutic approaches
of sepsis and septic shock. … and to more aggressive therapeutic approach, including earlier …

[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
… an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches
targeting different immunological mechanisms in the course of sepsis and septic shock, …

The endothelial glycocalyx: new diagnostic and therapeutic approaches in sepsis

L Martin, P Koczera, E Zechendorf… - BioMed research …, 2016 - Wiley Online Library
… and sepsis severity. In this review, we highlight the crucial role of the glycocalyx in sepsis
as a … serving as hopeful therapeutic targets in sepsis‐associated multiple organ failures. …

Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - … on therapeutic …, 2021 - Taylor & Francis
… clinically benefitted substantially from therapeutic approaches derived from reductionist
animal modeling including checkpoint proteins, designer T-cells, to name a few [Citation43–45]. …