… receptor expressed on myeloid cells (TREM)-1, is predicted to remove the current
subjectivity and uncertainty in the diagnosis and therapeutic monitoring of infection and sepsis. …

… potential therapies of sepsis and septic shock … therapeutic approaches, and the use of
well-designed clinical trials (3). Roger Bone likened the search for an effective therapy of sepsis to …

… This paradigm, which forms the basis of standard antimicrobial therapy of sepsis and septic
shock, suggests that elimination of the underlying infection should terminate the downstream …

… , have been targets for therapy in sepsis, a fundamental con… for hypotension and organ system
dysfunction in sepsis, … oxygenase products as a contributing cause to septic shock [11, 12, …

… The first definitions of sepsis, severe sepsis and septic shock were described in 1992 [3].
These were superseded in early 2016 by new definitions (Table 1) developed by an …

Abstract: The pathophysiology of sepsis and septic shock is … Available therapeutic
approaches with monoclonal … , adjuvant treatment of sepsis and septic shock with intravenous …

… therapeutic approaches available for sepsis that target inflammatory response; the mortality
of sepsis … There are no therapeutic approaches available for sepsis that target inflammatory …

… therapy. An inappropriate antibiotic prescription in critically ill septic patients can substantially
increase mortality (septic … extended empiric antibiotic therapy of severe sepsis/septic shock …

… In this review, we discuss the clinical and experimental basis of emerging therapeutic
approaches that focus on targeting early proinflammatory and late anti-inflammatory processes, as …

… a therapeutic approach in the management of sepsis. [ 45 ] Moreover, noncoding RNA
transcripts known as microRNAs (miRNAs), molecules capable of epigenetic reprogramming of …