… Rather, representative examples of the cytokines involved in some forms of cancer and … of
cytokines as therapeutic targets, and the overwhelming message is that “anti-cytokine medicine…

… Cytokines are therefore attractive therapeutic targets in these conditions. Anticytokine therapy
for … Finally, we report on the current state of trials for newer therapeutic targets, focusing …

… Cytokine research has spawned the introduction of new therapies that have revolutionized
the treatment of many … the introduction of cytokine and anti-cytokine therapies, with emphasis …

… Many cytokine pathways of importance in the pathogenesis of systemic lupus erythematosus
(SLE) have been identified and clinical trials of biologic agents targeting a number of these …

… 1A), describes the fact that many cytokines exhibit different … Many activities are shared
between different cytokines (Fig. 1B), an attribute called redundancy. Blocking one cytokine …

… cytokines regulates autoimmune diseases. On the basis of pre-clinical and clinical data, we
specifically discuss the therapeutic rationale for targeting these cytokines … that many new, …

… were not often co-expressed in cartilage, so that the potential for local cytokine inhibition …
[2] MMPs are capable of degrading many of the ECM proteins including proteoglycans, …

… the cytokine network in allergic disease. This article highlights the challenges of dissecting
the role of individual cytokines in … therapies which target Th1, Th2 and regulatory cytokines on …

… cytokines in atherosclerosis together with therapeutic … Many cytokines are expressed in
atherosclerotic plaques and all cells involved in the disease are capable of producing cytokines …

… Th1 cells can produce many cytokines that play important roles in the pathogenesis of liver
diseases (Fig. 1). Among them, both IFN-γ and TNFα have been extensively investigated over …