… innate immune response in mediating imiquimod’… imiquimod can also affect acquired immune
responses. Interferon-α is capable of potentiating the cellular arm of the immune response, …

… innate and cell-mediated immune response. A study was carried … of action of imiquimod 5%
cream when applied topically to … (3) evaluating effects of imiquimod on HPV DNA and gene …

… treated topically with imiquimod 5% cream. … response only when topical imiquimod was
intermittently supplemented by intralesional interleukin (IL)-2 for 2 weeks. Unwanted side effects …

… In summary, topically applied imiquimod induces cytokine production and secretion from …
Topical imiquimod cream provides signals to keratinocytes and the immune system so that it …

… A similar immune response is observed in genital wart patients after topical treatment of
imiquimod, as the messenger RNA levels for IFN‐α and IL‐12 and several other cytokines are …

… Topical imiquimod has also been tried for the treatment of various dermatological conditions,
including several precancerous skin lesions and forms of skin cancer ( Table 1 ). Although …

… seen after both systemic and topical application.5, 6 In animal studies, imiquimod has
demonstrated broad antiviral and antitumor effects that are largely mediated by IFN-α. In humans, …

… modifier commercially available as a 3.75 and 5% cream. Topical imiquimod stimulates the
innate and adaptive immune responses and induces cytokine production. This allows its use …

… Imiquimod may stimulate or enhance both the innate immune system and the acquired or
adaptive immune system.… Treatment of facial verrucae with topical imiquimod cream in a patient …

… in hairless mouse and rat skin after topical application of the immune response modifiers …
In conclusion, imiquimod represents a new class of immune response modifiers capable of …