… little in the way of translational insights necessary to use the … disease processes. The goal
of integrating these tools is to generate disease models that can be used for rapid translation, …

… of how Translational Systems Biology approaches are being … Translational Systems Biology
studies to date has been that the therapeutic goal for most, if not all, inflammatory diseases …

… We present 4 case studies of successful translational, interdisciplinary systems biology
efforts, which differ by organizational level from an individual to an entire research community. …

… processes in humans, inflammation and its manifestations in disease are significantly …
translational systems biology framework is strongly focused on understanding the human condition …

… As such, Translational Systems Biology is at an inflection point … of Translational Systems
Biology, including overviews of the inflammatory response in trauma, sepsis, infectious disease (…

… translational systems biology (TSB), an approach that uses multiscale dynamic computational
modeling to explicitly represent disease … focused on examining acute inflammation and its …

… This book introduces and demonstrates the Translational Systems Biology approach. … in
Translational Systems Biology as applied to disease states involving acute inflammation. In Part …

… and providing examples from existing work in Translational Systems Biology as applied to
the study of acute inflammation and critical illness. We consider the content of Sections 3 and …

… This structure is described in a consensus statement from the Society of Complexity in
Acute Illness regarding the process of evidence-based dynamic mathematical modeling. …

… and the development of effective therapies for various inflammatory conditions. We have
suggested the concept of translational systems biology, defined as a focused application of …