… an “engineering approach” to the burn patient to help translate the … we have termed
Translational Systems Biology (TSB) as a … of biological systems that exhibit the properties of …

… trials, patient … of translational systems biology, namely the use of mechanistic modeling to
gain insights into the pathophysiology of individuals (ie, patients) and populations (ie, patient …

… that is also required for repair and regeneration after injury. Despite the repository of detailed
data … EBM has also been used to study various facets of the inflammatory response to burn …

… The acute inflammatory response to biological stress (eg, infection or tissue injury/damage) …
Below, we discuss examples of how Translational Systems Biology approaches are being …

… trauma patients, the need to develop novel approaches by which to identify patients at risk
of adverse outcome is becoming increasingly important. Centred on the idea that patients who …

… To understand processes in the body’s response to a burn injury at a preclinical level, the
systems biology approach can be employed. … Translational systems biology of inflammation …

… injury, to advance mechanistic and translational research progress in TIC and explore the
applicability to burn … of our Systems Biology Coagulopathy of Trauma and Burn program and …

… We term this approach translational systems biology (25–27)… of the inflammatory response
to burns, including the effects of … is aimed ultimately at improving the clinical care of the patient…

… levels, drives outcomes following injury and infection and can … recognition and effective
reaction to injury or infection, acute … most dramatically manifest the Translational Dilemma. Indeed…

… profound injury to nerves. Depending on the location affected and burn depth, a burn victim
may … Translation into a useful technology that will improve wound healing and outcomes may …