… discoveries via an engineering paradigm. This is the translational dilemma that faces
biomedical research, and the reason for the development of Translational Systems Biology. While …

… paradigm, suggests that this modeling framework is well suited for translational systems
biology… This review describes agent-based modeling and gives examples of its translational …

… Moreover, we will also see that the Third Biological Thread, evolution, will also need to
be integrated into the biomedical research paradigm, and we will propose how this can be …

… to escape the “adaptive paradigm” of network evolution in population genetic … translational
research that does not have the capacity to incorporate systems biological and evolutionary …

… This comprehensive approach, which we call ‘Translational Systems Biology‘, to date has
been utilized for in silico studies of sepsis, trauma/hemorrhage/traumatic brain injury, acute …

… This kind of biological and clinical analysis of heart failure is … the two directions of systems
biology, functional composition (… systems biology approach, with a new conceptual paradigm …

… famous paradigm in the … computational biology has expanded rapidly during the first decade
of the twenty-first century and, through its contribution to what is now called systems biology…

… that these paradigms are inapt. Systems Biology does not quite converge with biology either:
… We shall examine whether these paradigms make sense in a Systems Biology that aims to …

… systems biology approaches that only tackle small-scale dynamical problems. … systems
approach is ultimately a paradigm that reflects what we understand about organismal evolution …

… ’ data and the rise of systems biology that now offers precise … systems and help to bridge
the gap between the formal description of theorists and the intuition of experimental biologists, …