[HTML][HTML] Regulation of PD-L1: a novel role of pro-survival signalling in cancer
… up-regulation of PD-L1 by oncogenic activation of EGFR in NSCLC [53]. Whether other growth
factors drive PD-L1 … factor has been shown to up-regulate PD-L1 in a mouse melanoma …
factors drive PD-L1 … factor has been shown to up-regulate PD-L1 in a mouse melanoma …
Regulation of PD-L1 expression in the tumor microenvironment
M Yi, M Niu, L Xu, S Luo, K Wu - Journal of hematology & oncology, 2021 - Springer
… homolog 2 negatively regulated PD-L1 expression by … regulated PD-L1 expression [30].
Inhibiting methylation of DNA by DNA methyltransferase inhibitors (DNMTis) increased PD-L1 …
Inhibiting methylation of DNA by DNA methyltransferase inhibitors (DNMTis) increased PD-L1 …
Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells
X Wang, L Yang, F Huang, Q Zhang, S Liu, L Ma… - Immunology letters, 2017 - Elsevier
… TNF-α may synergistically induce PD-L1 expression in human … PD-L1 mRNA expression,
but up-regulated PD-L1 protein expression in HCT116 and LNCaP cells. TNF-α induced PD-L1 …
but up-regulated PD-L1 protein expression in HCT116 and LNCaP cells. TNF-α induced PD-L1 …
[HTML][HTML] EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy
… of PD-L1 was suppressed by knocking down LMP1 in EBV positive cell lines. We further
demonstrated that LMP1 up-regulated PD-L1 … with LMP1 in up-regulating PD-L1 in NPC. …
demonstrated that LMP1 up-regulated PD-L1 … with LMP1 in up-regulating PD-L1 in NPC. …
Regulation of PD-L1 Expression by NF-κB in Cancer
F Antonangeli, A Natalini, MC Garassino… - Frontiers in …, 2020 - frontiersin.org
… several cytokines regulating PD-L1 expression. Two … PD-L1 up-regulation. Blue arrows
indicate activation of NF-kB pathway; black arrows indicate NF-κB-mediated PD-L1 up-regulation…
indicate activation of NF-kB pathway; black arrows indicate NF-κB-mediated PD-L1 up-regulation…
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
P Loke, JP Allison - … of the National Academy of Sciences, 2003 - National Acad Sciences
… Here, we find that Th1 and Th2 cells can differentially up-regulate PD-L1 and PD-L2 on
macrophages in the periphery; hence, they are the major determinant of the costimulatory …
macrophages in the periphery; hence, they are the major determinant of the costimulatory …
[HTML][HTML] The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines
T Ishikawa, T Okayama, K Oka… - Oncology …, 2017 - spandidos-publications.com
… PD-L1 upregulation, we sought to determine whether the JAK/STAT pathway regulates PD-L1
… , and JAK2 inhibitor AG490 reversed the upregulation of PD-L1 induced by the anticancer …
… , and JAK2 inhibitor AG490 reversed the upregulation of PD-L1 induced by the anticancer …
PD-1 and PD-L1 up-regulation promotes T-cell apoptosis in gastric adenocarcinoma
YM Chiu, CL Tsai, JT Kao, CT Hsieh… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: The programmed death 1 (PD-1) receptor and its ligand (PD-L1) play pivotal
roles in regulating host immune responses. However, the inhibitory effects of this pathway …
roles in regulating host immune responses. However, the inhibitory effects of this pathway …
Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells
Y Morimoto, T Kishida, S Kotani, K Takayama… - Biochemical and …, 2018 - Elsevier
… in PD-L1. mTOR may not be significantly involved in the regulation of PD-L1, whereas PI3-K
pathway played differential roles on PD-L1 mRNA and cell-surface PD-L1 expression, in the …
pathway played differential roles on PD-L1 mRNA and cell-surface PD-L1 expression, in the …
Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1
C Roux, SM Jafari, R Shinde… - Proceedings of the …, 2019 - National Acad Sciences
… ROS regulate PD-L1 expression and secretion of immunosuppressive cytokines in BMDMs.
(A) Pdl1 … Thus, we hypothesized that ROS might regulate PD-L1 expression through NF-κB …
(A) Pdl1 … Thus, we hypothesized that ROS might regulate PD-L1 expression through NF-κB …