Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction …

M Gheorghiade, SJ Greene, J Butler, G Filippatos… - Jama, 2015 - jamanetwork.com
… Clinical profile and prognostic significance of natriuretic peptide trajectory following
hospitalization for worsening chronic heart failure: findings from the ASTRONAUT trial. Eur J Heart

… in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with …

B Pieske, AP Maggioni, CSP Lam… - European heart …, 2017 - academic.oup.com
… Direct stimulators of sGC differ from other agents targeting the cGMP pathway in … of worsening
chronic heart failure (HF) requiring hospitalization where, after discharge, cardiovascular

Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum

J Butler, MS Usman, KJ Anstrom… - … of Heart Failure, 2022 - Wiley Online Library
… Evaluating sGC stimulators in a trial with a longer follow-up in patients without worsening heart
failure … Moreover, the potential anti-remodelling effects of sGC stimulators may reduce the …

Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)

B Pieske, J Butler, G Filippatos, C Lam… - … of heart failure, 2014 - Wiley Online Library
… The clinical outcomes for patients with worsening chronic heart failure (WCHF) remain …
cyclase (sGC) stimulators target reduced cGMP generation due to insufficient sGC stimulation

[HTML][HTML] Soluble guanylate cyclase stimulators in heart failure

S Kansakar, A Guragain, D Verma, P Sharma… - Cureus, 2021 - ncbi.nlm.nih.gov
cyclase stimulators have significant benefits in reducing hospitalizations in patients with heart
failure with … Poor response to natriuretic peptides leads to worsening of the vicious cycle of …

Soluble guanylate cyclase activators and stimulators in patients with heart failure

WL Liang, B Liang - Current Cardiology Reports, 2023 - Springer
… SOCRATES-REDUCED indicated that among patients with worsening chronic HF (LVEF
≤ 45%), it is suggested that a dose–response relationship that higher vericiguat doses were …

[HTML][HTML] Development of vericiguat: The first soluble guanylate cyclase (sGC) stimulator launched for heart failure with reduced ejection fraction (HFrEF)

J Xia, N Hui, L Tian, C Liang, J Zhang, J Liu… - Biomedicine & …, 2022 - Elsevier
… for heart failure (HF), the survival period of patients has been extended. However, the
emergence of some patients with repeated hospitalizations due to their worsening conditions and …

The efficacy and safety of soluble guanylate cyclase stimulators in patients with heart failure: A systematic review and meta-analysis

X Zheng, W Zheng, B Xiong, J Huang - Medicine, 2018 - journals.lww.com
… in the setting of worsening chronic heart failure. The nitric … guanylate cyclase stimulator in
heart failure patients with preserved … guanylate cyclase stimulator in heart failure patients with

Soluble guanylate cyclase stimulators: a novel treatment option for heart failure associated with cardiorenal syndromes?

RF Dubin, SJ Shah - Current heart failure reports, 2016 - Springer
… trials involved patients recently hospitalized with worsening HF, a time during which renal
… In addition, patients with worsening chronic HF (such as those enrolled in the SOCRATES …

Vericiguat: a novel oral soluble guanylate cyclase stimulator for the treatment of heart failure

N Campbell, J Kalabalik-Hoganson… - Annals of …, 2022 - journals.sagepub.com
… of HF, with New York Heart Association (NYHA) functional … clinical stability of worsening
chronic HF requiring hospitalization or … concluded that in patients with worsening chronic HF and …