… in organ size control. Once we decipher the mechanical and biochemical signals that control
the function of YAP and TAZ, we … in cancer treatment, tissue regrowth or organ regeneration. …

… of organ size in both Drosophila and mammals. Acting downstream of the Hippo pathway
is the Yki/YAP/TAZ … the mechanism of YAP and TAZ in control of cell growth and organ size. …

… Yes-associated protein (YAP)/TAZ transcription coactivators … YAP/TAZ inhibition affects cell
number by repressing cell proliferation and promoting apoptosis, thereby limiting organ size. …

… YAP/TAZ activation (for simplicity, in this Review, we treat YAP and TAZ as equivalent proteins
(YAP/TAZ… ) in stimulating organ repair and regeneration in non-regenerating organs, with …

… and the Hippo pathway may indeed represent a valuable target for cancer therapy and that
more opportunities will emerge as we learn more on the role of YAP/TAZ in organ growth and …

… In addition, these studies highlight the complexity of Yap/Taz regulation at the … organ size
regulation. Given the proposed importance of Yap and Taz in controlling mammalian organ size…

… -suppressor pathway in the regulation of organ size. Dysregulation of this pathway leads to
… organ size by phosphorylating and inhibiting the transcription co-activators YAP and TAZ in …

… to play key roles in tumorigenesis and organ maintenance. Here, we report that YAP/TAZ
directly promote FOS transcription that in turn contributes to the biological function of YAP/TAZ. …

… key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription
co… uncovering the mystery of organ size control and identify new targets for cancer treatment. …

… do not know how YAP/TAZ realize their most remarkable trademark feature: the growth of
organs until they reach their correct size. Then, as detailed in this review, YAP/TAZ are mainly …