▪ Abstract Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are
providing new insights into the regulatory functions of the myogenic regulatory factors …

Unraveling the complex tissue interactions necessary to generate the structural and
functional diversity present among craniofacial muscles is challenging. These muscles …

Transcription factors and DNA regulatory binding motifs are fundamental components of the
gene regulatory network. Here, by using genome-wide binding profiling, we show extensive …

Technologies that enable targeted manipulation of epigenetic marks could be used to
precisely control cell phenotype or interrogate the relationship between the epigenome and …

MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and
protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and …

Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful
technologies to synthetically reshape the human epigenome and gene expression. Despite …

Satellite cells are tissue-specific stem cells responsible for skeletal muscle growth and
regeneration. Although satellite cells were identified almost 50 years ago, the identity of …

Members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors control the
formation of all skeletal muscles in vertebrates, but little is known of the molecules or …

Using Hi-C, promoter-capture Hi-C (pCHi-C), and other genome-wide approaches in
skeletal muscle progenitors that inducibly express a master transcription factor, Pax7, we …

Previous studies have indicated that myoblasts can differentiate and repair muscle injury
after an ischemic insult. However, it is unclear how hypoxia or glucose deprivation in the …