Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

Overcrowding conditions and temperatures shifts regularly manifest in large-scale infections
of farmed fish, resulting in economic losses for the global aquaculture industries. Increased …

While the mammalian macrophage phenotypes have been intensively studied in vitro, the
dynamic of their phenotypic polarization has never been investigated in live vertebrates. We …

Neutrophils play a pivotal role in the innate immune response. The small cytokine CXCL8
(also known as IL-8) is known to be one of the most potent chemoattractant molecules that …

The aim of the current study was to investigate the effects of glucosamine (GlcN) on septic
lethality and sepsis-induced inflammation using animal models of mice and zebrafish. GlcN …

Studying macrophage biology in the context of a whole living organism provides unique
possibilities to understand the contribution of this extremely dynamic cell subset in the …

Toll-like receptors (TLRs) are an important class of pattern recognition receptors (PRRs) that
recognize microbial and danger signals. Their downstream signaling upon ligand binding is …

Tuberculosis is a current major world-health problem, exacerbated by the causative
pathogen, Mycobacterium tuberculosis (Mtb), becoming increasingly resistant to …

Macrophages are found across all vertebrate species, reside in virtually all animal tissues,
and play critical roles in host protection and homeostasis. Various mechanisms determine …

Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …