As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a
human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide …

Children differ from adults in many aspects of pharmacotherapy, including capabilities for
drug administration, medicine-related toxicity, and taste preferences. It is essential that …

A number of anatomical and physiological factors determine the pharmacokinetic profile of a
drug. Differences in physiology in paediatric populations compared with adults can influence …

Many physiologic differences between children and adults may result in age-related
changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and …

The advent of nanotechnological products in the market, while holding great promise, is
raising concerns in consumers. Therefore, this contribution will attempt to compare different …

Despite much progress in regulations to improve paediatric drug development, there
remains a significant need to develop better medications for children. For the design of oral …

The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting
considerable advantages, has created challenges for researchers. Among the applications …

The total number of paediatric formulations available only account for a small proportion of
the full therapeutic plethora required to effectively treat paediatrics and, therefore, the …

Background Tuberous sclerosis complex (TSC) is a multisystem disease with prominent
neurologic manifestations such as epilepsy, cognitive impairment and autism spectrum …

This chapter introduces the current state of the science relating to skin absorption of
nanoparticles (NPs) based on the 10 parameters of percutaneous penetration. It starts by …