Although the majority of oxidative metabolic reactions are mediated by the CYP superfamily
of enzymes, non-CYP-mediated oxidative reactions can play an important role in the …

Absence of safe, effective and appropriate treatment is one of the main causes of high
mortality and morbidity rates among the pediatric group. This review provides an overview of …

Introduction: There are profound changes that take place in drug metabolism enzymes
during fetal and postnatal development. These changes may significantly impact drug …

This review focuses on one of the key factors accounting for differences in drug/metabolite
exposure in paediatric and elderly subjects compared with that of the adult population, that …

The development of therapeutics for pediatric use has advanced in the last few decades.
However, off-label use of adult medications in pediatrics remains a significant clinical …

Objective The present analysis examined the exposure‐response relationship by means of
the predose everolimus concentration (Cmin) and the seizure response in patients with …

Precision medicine is an emerging paradigm that aims at maximizing the benefits and
minimizing the adverse effects of drugs. Realistic mechanistic models are needed to …

This article reports on the development of UDP-glucuronosyltransferase (UGT) enzyme
activity in pediatric livers. The substrates 4-methylumbelliferone (4MU) and trifluoperazine …

Very little is known about the effect of gut microbiota on the ontogeny of drug-processing
genes (DPGs) in liver. In this study, livers were harvested from conventional (CV) and germ …

The frequent presence of deoxynivalenol (DON) in cereal-based foods and the high intake
of these foods by children raises particular concerns about the relative susceptibility of this …