[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

The mechanisms of nanoparticle delivery to solid tumours

LNM Nguyen, W Ngo, ZP Lin, S Sindhwani… - Nature Reviews …, 2024 - nature.com
Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

RE Veerman, L Teeuwen, P Czarnewski… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are increasingly tested as therapeutic vehicles and biomarkers,
but still EV subtypes are not fully characterised. To isolate EVs with few co‐isolated entities …

[HTML][HTML] The ins and outs of lipid rafts: Functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: Thematic Review Series: Biology of …

AB Ouweneel, MJ Thomas, MG Sorci-Thomas - Journal of lipid research, 2020 - ASBMB
Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated
into microdomains on the basis of preferential association between specific lipids and …

Different isolation approaches lead to diverse glycosylated extracellular vesicle populations

D Freitas, M Balmaña, J Poças, D Campos… - Journal of …, 2019 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous group of small secreted particles involved
in intercellular communication and mediating a broad spectrum of biological functions. EVs …

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

M Kurzawa‐Akanbi, P Whitfield, F Burté… - Journal of …, 2022 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is
caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal …

[HTML][HTML] Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein

S Busatto, Y Yang, SA Walker, I Davidovich… - Journal of …, 2020 - Springer
Background Cancer cell-derived extracellular vesicles (EVs) have previously been shown to
contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro …

[HTML][HTML] Extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges

A Oshchepkova, M Zenkova, V Vlassov - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …

[HTML][HTML] Plant extracellular vesicles: A novel bioactive nanoparticle for tumor therapy

ZL Tan, JF Li, HM Luo, YY Liu, Y Jin - Frontiers in Pharmacology, 2022 - frontiersin.org
Extracellular vesicles are tiny lipid bilayer-enclosed membrane particles, including apoptotic
bodies, micro vesicles, and exosomes. Organisms of all life forms can secrete extracellular …

[HTML][HTML] Focused ultrasound hyperthermia augments release of glioma-derived extracellular vesicles with differential immunomodulatory capacity

ND Sheybani, AJ Batts, AS Mathew, EA Thim… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Increasing evidence points to the critical role of extracellular vesicles (EVs) as
molecular parcels that carry a diverse array of bioactive payloads for coordination of …