DNA methylation plays an important role in gene regulation in animals. However, the
evolution and function of DNA methylation has only recently emerged as the subject of …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

Several lines of evidence point to the early origin of adult onset disease. A key question is:
what are the mechanisms that mediate the effects of the early environment on our health …

To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …

Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …

Cell‐selective glucocorticoid receptor (GR) binding to distal regulatory elements is
associated with cell type‐specific regions of locally accessible chromatin. These regions can …

One of the most exciting discoveries in the learning and memory field in the past two
decades is the observation that active regulation of gene expression is necessary for …

A systems understanding of nuclear organization and events is critical for determining how
cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases …

DNA methylation occurring on the 5 position of the pyrimidine ring of cytosines in the context
of the dinucleotide sequence CpG forms one of the multiple layers of epigenetic …

The base excision repair (BER) pathway is a frontline defender of genomic integrity and
plays a central role in epigenetic regulation through its involvement in the erasure of 5 …