Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Long noncoding RNAs: Novel insights into hepatocelluar carcinoma

Y He, XM Meng, C Huang, BM Wu, L Zhang, XW Lv… - Cancer letters, 2014 - Elsevier
Recent advances in non-protein coding part of human genome analysis have discovered
extensive transcription of large RNA transcripts that lack of coding protein function, termed …

[PDF][PDF] DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma

A Villanueva, A Portela, S Sayols, C Battiston… - …, 2015 - Wiley Online Library
Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …

Common DNA methylation alterations in multiple brain regions in autism

C Ladd-Acosta, KD Hansen, E Briem, MD Fallin… - Molecular …, 2014 - nature.com
Autism spectrum disorders (ASD) are increasingly common neurodevelopmental disorders
defined clinically by a triad of features including impairment in social interaction, impairment …

[HTML][HTML] Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg

MG Fernández-Barrena, M Arechederra, L Colyn… - Jhep Reports, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

Exploration of liver cancer genomes

T Shibata, H Aburatani - Nature reviews Gastroenterology & hepatology, 2014 - nature.com
Liver cancer is the third leading cause of cancer-related death worldwide. Advances in
sequencing technologies have enabled the examination of liver cancer genomes at high …

Epigenetics of hepatocellular carcinoma

TB Toh, JJ Lim, EKH Chow - Clinical and translational medicine, 2019 - Springer
In recent years, large scale genomics and genome-wide studies using comprehensive
genomic tools have reshaped our understanding of cancer evolution and heterogeneity …

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

A Gagliardi, VL Porter, Z Zong, R Bowlby, E Titmuss… - Nature …, 2020 - nature.com
Cervical cancer is the most common cancer affecting sub-Saharan African women and is
prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer …

Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

J Cheng, D Wei, Y Ji, L Chen, L Yang, G Li, L Wu… - Genome medicine, 2018 - Springer
Background Hepatocellular carcinoma (HCC) is the one of the most common cancers and
lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and …

Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

HG Woo, JH Choi, S Yoon, BA Jee, EJ Cho… - Nature …, 2017 - nature.com
Hepatocellular carcinoma harbors numerous genomic and epigenomic aberrations of DNA
copy numbers and DNA methylation. Transcriptomic deregulation by these aberrations plays …